952591-72-9

Upstream product

• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 100-63-0 phenylhydrazine 
• 90-02-8 salicylaldehyde 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 372098-13-0 3-(1-benzofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 1200127-31-6 1-((3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-cyclohexylthiosemicarbazide 
• 379223-77-5 3-(3-benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl-1-phenylprop-2-en-1-one 
• 797000-59-0 3-(3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-1-(4-chlorophenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Divergent Carbocatalytic Routes in Oxidative Coupling of Benzofused Heteroaryl Dimers: A Mechanistic Update

Mildly thermal air or HNO3 oxidized activated carbons catalyse oxidative dehydrogenative couplings of benzo[b]fused heteroaryl 2,2’-dimers, e.g., 2-(benzofuran-2-yl)-1H-indole, to chiral 3,3’-coupled cyclooctatetraenes or carbazole-type migrative products under O2 atmosphere. DFT calculations show that the radical cation and the Scholl-type arenium cation mechanisms lead to different products with 2-(benzofuran-2-yl)-1H-indole, being in accord with experimental product distributions.

Synthesis, biological evaluation and molecular dynamic simulations of novel Benzofuran-tetrazole derivatives as potential agents against Alzheimer's disease

A series of novel Benzofuran-tetrazole derivatives were successfully synthesised by integrating multicomponent Ugi-azide reaction with the molecular hybridization approach. Interestingly, a number of synthesized derivatives (5c, 5d, 5i, 5l, 5q and 5s) exhibited significant reduction of aggregation of “human” amyloid beta peptide, expressing on transgenic Caenorhabditis elegans (C. elegans) strain CL4176. Further, in silico docking results have evidenced the exquisite interaction of active compounds with the help of TcAChE–E2020 complex. These findings underscore the potential of these hybrids as lead molecules against Alzheimers's disease.

Design, synthesis and evaluation of novel benzimidazoles, benzothiazoles and benzofurans incorporating pyrazole moiety as antiangiogenic agents

Novel benzimidazoles, benzothiazoles and benzofurans incorporating pyrazole moiety have been synthesized and screened for their antiangogenic activities, by testing their ability to inhibit human umbilical vein endothelial cell (HUVEC) proliferation, cord formation and migration in response to chemoattractant. 3 compounds 19, 23 and 26 showed antiangiogenic activities at non-cytotoxic concentrations. Compound 19 was the most active with chemotaxis activity data nearly comparable to that of the positive control, TNP-470. Compound 42 showed a significant cytotoxic effect on the tested cancer cell lines and less antiangiogenesis activity compared to compounds 19, 23 and 26. All the tested compounds, in contrary to TNP-470, interfered with the migratory function of HUVECs in response to vascular endothelial growth factor rather than the endothelial cells proliferation or cord formation. Moreover, a docked pose of compounds 19 and 26 was obtained bound to kinase insert domain receptor using Molecular Operating Environment module. Georg Thieme Verlag KG · Stuttgart · New York.

A convenient synthesis of 2(2-benzo[b]furo) indoles and benzofuropyrazoles

A short synthesis of benzo[b]furo indolyls 3a-g from 2-acetylbenzofuran 1 in two steps and corresponding pyrazoles 4a-g is described. An interesting scale-up procedure for the synthesis of 2-acetylbenzofuran is also been reported. Similarly 2-acetylbenzofurohydrazones 2a-g is prepared from 2-acetyl benzofuran and with various phenylhydrazine hydrochlorides in presence of CH3COONa/EtOH at RT in excellent yield (90-95%). These 2-acetyl benzofurohydrazones 2a-g are subjected to Fiseher indole cyelisation in presence of ZnCl2 in acetonitrile as solvent to get 2(2-benzo[b]furo)indolcs 3a-g in good yield.