952648-00-9Relevant academic research and scientific papers
Synthesis and molecular docking study of pyrazole clubbed oxazole as antibacterial agents
Desai, Nisheeth C.,Vaja, Darshita V.,Joshi, Surbhi B.,Khedkar, Vijay M.
, p. 573 - 587 (2020/10/19)
Abstract: We have developed a simple synthetic protocol for the preparation of novel 3-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-arylisoxazoles. The structure of synthesized compounds was elucidated by spectral techniques like FT-IR, 1H-NMR, 13C-NMR, and mass. The novel bioactive compounds 3a-t were evaluated for in vitro antibacterial activity on several bacterial species. Compounds 3c (–4–NO2), 3o (–4–F), and 3r (–3,4–Cl2) exhibited good in vitro antibacterial activity. Furthermore, molecular docking on?DNA gyrase subunit b could shed some light on the mechanism of action which can serve as a guide for lead optimization. Graphic abstract: [Figure not available: see fulltext.]
Facile synthesis of novel fluorine containing pyrazole based thiazole derivatives and evaluation of antimicrobial activity
Desai,Joshi,Rajpara,Vaghani,Satodiya
, p. 67 - 78 (2012/11/07)
A series of compounds 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3- (aryl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-ones (4a-q) were synthesized and structures of these compounds were elucidated by spectral (IR, 1H NMR, 13C
Synthesis and antibacterial activity of some new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones
Prakash, Om,Kumar, Rajesh,Sehrawat, Rakesh
scheme or table, p. 1763 - 1767 (2009/06/18)
Seven new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones (5) have been synthesized by the oxidation of 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromones (4) with iodobenzene diacetate in methanol. The structures of compounds 5 were es
