952649-42-2

Upstream product

• 59779-75-8 diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate 
• 2113-57-7 3-bromobiphenyl 
• 98-80-6 phenylboronic acid 
• 591-18-4 1-Bromo-3-iodobenzene 

Downstream Products

• 1352731-49-7 C₅₇H₄₄N₂O₂ 
• 1352731-56-6 C₅₇H₄₉NO₂ 
• 1352731-64-6 Br^(1-)*C₆₁H₅₆NO₂⁽¹⁺⁾ 
• 952649-47-7 3-{[(3aR,8aR)-4,4,8,8-tetra-1,1'-biphenyl-3-yl-2,2-dimethyl-6-oxidotetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]oxy}propanenitrile 

Relevant academic research and scientific papers

Enantioselective cyclopropanation with TADDOL-derived phosphate ligands

The synthesis of new chiral TADDOL-derived phosphate ligands is described. The ligands were efficiently synthesized on a multi-gram scale in three steps starting from the readily available corresponding TADDOL and were fully characterized. An X-ray structure was obtained and compared to known BINOL-phosphates. Their use in the asymmetric Simmons-Smith cyclopropanation of both functionalized and unfunctionalized olefins gave the desired cyclopropanes in good yields and good to moderate enantioselectivities.