952652-90-3Relevant academic research and scientific papers
Lipopeptide with a RGDK tetrapeptide sequence can selectively target genes to proangiogenic α5β1 integrin receptor and mouse tumor vasculature
Pramanik, Dipankar,Majeti, Bharat K.,Mondal, Goutam,Karmali, Priya P.,Sistla, Ramakrishna,Ramprasad, Obula G.,Srinivas, Gunda,Pande, Gopal,Chaudhuri, Arabinda
supporting information; experimental part, p. 7298 - 7302 (2009/11/30)
Integrins, the major class of αβ heterodimeric transmembrane glycoprotein receptors, play crucial roles in mediating tumor angiogenesis. Genetic ablation experiments combined with use of antibodies/peptide ligands for blocking either α5 or βsu
NOVEL INTEGRIN BINDING RGD-LIPOPEPTIDES WITH GENE TRANSFER ACTIVITIES
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Page/Page column 10; 18-19, (2008/06/13)
The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides phenomenally high L27 (transformed Sl 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since L27 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).
