952652-92-5Relevant academic research and scientific papers
Lipopeptide with a RGDK tetrapeptide sequence can selectively target genes to proangiogenic α5β1 integrin receptor and mouse tumor vasculature
Pramanik, Dipankar,Majeti, Bharat K.,Mondal, Goutam,Karmali, Priya P.,Sistla, Ramakrishna,Ramprasad, Obula G.,Srinivas, Gunda,Pande, Gopal,Chaudhuri, Arabinda
, p. 7298 - 7302 (2008)
Integrins, the major class of αβ heterodimeric transmembrane glycoprotein receptors, play crucial roles in mediating tumor angiogenesis. Genetic ablation experiments combined with use of antibodies/peptide ligands for blocking either α5 or βsu
NOVEL INTEGRIN BINDING RGD-LIPOPEPTIDES WITH GENE TRANSFER ACTIVITIES
-
Page/Page column 10; 19, (2008/06/13)
The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides phenomenally high L27 (transformed Sl 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since L27 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).
