952653-63-3Relevant academic research and scientific papers
Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone
Li, Xianfeng,Zhang, Yong-Kang,Plattner, Jacob J.,Mao, Weimin,Alley,Xia, Yi,Hernandez, Vincent,Zhou, Yasheen,Ding, Charles Z.,Li, Jinpeng,Shao, Zhijun,Zhang, Hongwei,Xu, Musheng
, p. 963 - 966 (2013/03/13)
We have designed and synthesized a novel class of compounds based on fluoroquinolone antibacterial prototype. The design concept involved the replacement of the 3-carboxylic acid in ciprofloxacin with an oxaborole-fused ring as an acid-mimicking group. The synthetic method employed in this work provides a good example of incorporating boron atom in complex molecules with multiple functional groups. The antibacterial activity of the newly synthesized compounds has been evaluated.
Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice
Tehler, Ulrika,Fagerberg, Jonas H.,Svensson, Richard,Larhed, Mats,Artursson, Per,Bergstr?m, Christel A. S.
, p. 2690 - 2694 (2013/05/21)
Esterification was used to simultaneously increase solubility and permeability of ciprofloxacin, a biopharmaceutics classification system (BCS) class 4 drug (low solubility/low permeability) with solid-state limited solubility. Molecular flexibility was i
Identification, biological activity, and mechanism of the anti-ischemic quinolone analog
Park, Chan-Hee,Lee, Jongwon,Jung, Hwi Young,Kim, Min Ji,Lim, Sun Ha,Yeo, Hyung Tae,Choi, Eung Chil,Yoon, Eun Jeong,Kim, Kyu Won,Cha, Jong Ho,Kim, Seok-Ho,Chang, Dong-Jo,Kwon, Do-Yeon,Li, Funan,Suh, Young-Ger
, p. 6517 - 6526 (2008/04/05)
The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myoc
