952653-63-3Relevant academic research and scientific papers
Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice
Tehler, Ulrika,Fagerberg, Jonas H.,Svensson, Richard,Larhed, Mats,Artursson, Per,Bergstr?m, Christel A. S.
, p. 2690 - 2694 (2013/05/21)
Esterification was used to simultaneously increase solubility and permeability of ciprofloxacin, a biopharmaceutics classification system (BCS) class 4 drug (low solubility/low permeability) with solid-state limited solubility. Molecular flexibility was i
Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone
Li, Xianfeng,Zhang, Yong-Kang,Plattner, Jacob J.,Mao, Weimin,Alley,Xia, Yi,Hernandez, Vincent,Zhou, Yasheen,Ding, Charles Z.,Li, Jinpeng,Shao, Zhijun,Zhang, Hongwei,Xu, Musheng
, p. 963 - 966 (2013/03/13)
We have designed and synthesized a novel class of compounds based on fluoroquinolone antibacterial prototype. The design concept involved the replacement of the 3-carboxylic acid in ciprofloxacin with an oxaborole-fused ring as an acid-mimicking group. The synthetic method employed in this work provides a good example of incorporating boron atom in complex molecules with multiple functional groups. The antibacterial activity of the newly synthesized compounds has been evaluated.
Identification, biological activity, and mechanism of the anti-ischemic quinolone analog
Park, Chan-Hee,Lee, Jongwon,Jung, Hwi Young,Kim, Min Ji,Lim, Sun Ha,Yeo, Hyung Tae,Choi, Eung Chil,Yoon, Eun Jeong,Kim, Kyu Won,Cha, Jong Ho,Kim, Seok-Ho,Chang, Dong-Jo,Kwon, Do-Yeon,Li, Funan,Suh, Young-Ger
, p. 6517 - 6526 (2008/04/05)
The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myoc
