952664-59-4

Usage

Type of compound

Methyl ester derivative of cyclopropanecarboxylic acid

Cyclopropane ring

A three-membered carbon ring

Carboxylic acid group

A functional group containing a carbonyl (C=O) and a hydroxyl (-OH) group

Phenyl group

A six-membered aromatic ring with alternating single and double carbon-carbon bonds

Carboxy-ethoxy substituent

A functional group containing a carboxylic acid group and an ethoxy (-OCH2CH3) group

Substituent position

Para (on the phenyl group)

Pharmaceutical

Development of new drugs

Medicinal

Research into biological and chemical properties of similar compounds

Upstream product

• 779199-69-8 1-(4-hydroxyphenyl)cyclopropanecarboxylic acid methyl ester 
• 779206-51-8 1-(4-methoxyphenyl)cyclopropanecarboxylic acid methyl ester 
• 16728-01-1 1-(4-methoxyphenyl)-1-cyclopropanecarboxylic acid 
• 952664-58-3 1-[4-(2-tert-butoxycarbonyl-ethoxy)phenyl]cyclopropanecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.