952687-99-9Relevant academic research and scientific papers
Rhodium(I)-catalyzed intramolecular hydroacylation of 4,6-dienals: Novel synthesis of cycloheptenones
Oonishi, Yoshihiro,Mori, Miwako,Sato, Yoshihiro
, p. 2323 - 2336 (2008/02/13)
Rhodium(I)-catalyzed hydroacylation of 4,6-dienals was investigated. Hydroacylation of 4,6-dienals with a substituent at the C7 position produced cycloheptenone derivatives as the major products, while the cyclization of 4,6-dienals with no substituent at the terminus of the diene moiety preferentially gave cyclopentanone derivatives. The olefinic geometry of the diene moiety in 4,6-dienals also affected the reaction course, and the cyclization of substrates with an E-olefin at the C6 position produced cycloheptenone derivatives as the major products, while a cyclopentanone derivative was obtained from a substrate with a Z-olefin at the C6 position. Georg Thieme Verlag Stuttgart.
