95272-94-9

Upstream product

• 102917-45-3 (S)-4,4,4-Trichloro-3-methyl-butyric acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester 

Downstream Products

• 1207193-62-1 C₁₄H₁₆Cl₃NO₃ 
• 1207193-63-2 C₁₄H₁₆Cl₃NO₃ 
• 65647-65-6 dysidenin 
• 91279-96-8 dysidin 
• 76527-12-3 (S)-4,4,4-Trichloro-3-methyl-butyric acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF ENANTIOMERICALLY PURE (S)-3-TRICHLOROMETHYLBUTYRIC ACID VIA ASYMMETRIC CONJUGATE ADDITION OF TRICHLOROMETHYL METAL COMPOUNDS TO A CHIRAL ENOATE. ACTIVATION EFFECT OF A SULFONYLAMINO GROUP.

(+)(S)-3-Trichloromethylbutyric acid, a building block for synthesis of various marine natural products, can be prepared via 99:1 stereoselective conjugate addition of Cl3CMgCl to the crotonate of a chiral auxiliary containing a sulfonylamino substituent.