SYNTHESIS OF ENANTIOMERICALLY PURE (S)-3-TRICHLOROMETHYLBUTYRIC ACID VIA ASYMMETRIC CONJUGATE ADDITION OF TRICHLOROMETHYL METAL COMPOUNDS TO A CHIRAL ENOATE. ACTIVATION EFFECT OF A SULFONYLAMINO GROUP.

DOI: 10.1016/S0040-4039(00)95121-9

Source and publish data:

Tetrahedron Letters p. 6047 - 6050 (1985)

Update date:2022-08-04

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Authors:

Helmchen, Guenter

Wegner, Guenter

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Article abstract of DOI:10.1016/S0040-4039(00)95121-9

(+)(S)-3-Trichloromethylbutyric acid, a building block for synthesis of various marine natural products, can be prepared via 99:1 stereoselective conjugate addition of Cl3CMgCl to the crotonate of a chiral auxiliary containing a sulfonylamino substituent.

Full text of DOI:10.1016/S0040-4039(00)95121-9

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