952741-98-9

Upstream product

• 14088-14-3 (8α,9β,13α,14β,17α)-3-methoxyestra-1,3,5(10)-trien-17-ol 
• 62-23-7 4-nitro-benzoic acid 
• 25112-95-2 toluene-4-sulfonic acid 2-(3-methoxyphenyl)-ethyl ester 
• 1798-09-0 m-methoxyphenylacetic acid 
• 5020-41-7 2-(3-methoxyphenyl)-ethanol 
• 428439-33-2 (8α,9β,13α,14β,17α)-17-(1,1-dimethylethoxy)-3-methoxyestra-1,3,5(10)-triene 
• 428439-28-5 (8α,13α,14β,17α)-17-(1,1-dimethylethoxy)-3-methoxyestra-1,3,5(10),9(11)-tetraene 
• 428439-27-4 (1R,3aR,4R,7aR)-1-(1,1-dimethylethoxy)octahydro-4-[2-(3-methoxyphenyl)ethyl]-7a-methyl-5H-inden-5-one 
• 428439-26-3 (1R,3aR,4S,7aR)-1-(1,1-dimethylethoxy)octahydro-4-[2-(3-methoxyphenyl)ethyl]-7a-methyl-5H-inden-5-one 
• 428439-23-0 (1R,7aR)-1-(1,1-dimethylethoxy)-1,2,3,6,7,7a-hexahydro-4-[2-(3-methoxyphenyl)ethyl]-7a-methyl-5H-inden-5-one 

Relevant academic research and scientific papers

A facile total synthesis of ent-17β-estradiol and structurally related analogues

A facile six-step synthesis (15.2% yield) of ent-17β-estradiol from readily accessible precursors is described. The preparation of analogues with 2-alkyl substituents, double bond unsaturation in the C-ring, a cis C,D-ring fusion and modified substituents at C17 is also reported.