953-76-4

Basic information

• Product Name: 6'-chloro-2',3'-dihydrospiro[cyclohexane-1,2'-quinazoline]-4'(1'H)-one
• Synonyms: 6'-chloro-2',3'-dihydrospiro[cyclohexane-1,2'-quinazoline]-4'(1'H)-one
• CAS NO: 953-76-4
• Molecular Formula: C13H15ClN2O
• Molecular Weight: 250.724
• Mol File: 953-76-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6'-chloro-2',3'-dihydrospiro[cyclohexane-1,2'-quinazoline]-4'(1'H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6'-chloro-2',3'-dihydrospiro[cyclohexane-1,2'-quinazoline]-4'(1'H)-one(953-76-4)
• EPA Substance Registry System: 6'-chloro-2',3'-dihydrospiro[cyclohexane-1,2'-quinazoline]-4'(1'H)-one(953-76-4)

Safety Data

• Hazardous Substances Data: 953-76-4(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 5202-85-7 2-Amino-5-chlorobenzamide 
• 108-94-1 cyclohexanone 
• 5922-60-1 2-amino-5-chlorobenzonitrile 

Relevant articles and documents

Synthesis of Flavanone and Quinazolinone Derivatives from the Ruthenium-Catalyzed Deaminative Coupling Reaction of 2′-Hydroxyaryl Ketones and 2-Aminobenzamides with Simple Amines

The cationic Ru–H complex [(C6H6)(PCy3)(CO)RuH]+BF4– (1) with 3,4,5,6-tetrachloro-1,2-benzoquinone (L1) was found to be a highly effective catalyst for the deaminative coupling reaction of 2′-hydroxyaryl ketones with simple amines to form 3-substituted flavanone products. The analogous deaminative coupling reaction of 2-aminobenzamides with branched amines directly formed 3,3-disubstituted quinazolinone products. The catalytic method efficiently installs synthetically useful flavanone and quinazolinone core structures without employing any reactive reagents.

Investigation of the reaction of o-aminonitriles with ketones: A new modification of Friedl?nder reaction and structures of its products

A new modification of the Friedl?nder reaction is described and the new byproduct obtained from the reaction of o-aminonitriles and ketones was found to be 2,3-dihydroquinazolin-4(1H)-one. The mechanism probably involved the formation of an intermediate o

Facile synthesis of 2,3-dihydro-2-aryl-4(1H)-quinazolinones promoted by Sml2

2,3-Dihydro-2-aryl-4(1H)-quinazolinones were prepared in good yields via reductive cyclisation of o-azidobeneamides with aldehydes and ketones promoted by Sml2 under mild and neutral conditions.