953029-02-2Relevant academic research and scientific papers
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds
Lawrence, Harshani R.,Pireddu, Roberta,Chen, Liwei,Luo, Yunting,Sung, Shen-Shu,Szymanski, Ann Marie,Yip, M. L. Richard,Guida, Wayne C.,Sebti, Sa?d M.,Wu, Jie,Lawrence, Nicholas J.
experimental part, p. 4948 - 4956 (2009/07/11)
Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199), which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC50 of 47 μM. A focused library incorporating an isatin scaffold was designed a
INHIBITION OF SHP2/PTPN11 PROTEIN TYROSINE PHOSPHATASE BY NSC-87877, NSC-117199 AND THEIR ANALOGS
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Page/Page column 27-28, (2010/11/28)
Compounds and associated methods for inhibiting a protein tyrosine phosphatase. By a combination of experimental and virtual screenings of the NCI Diversity Set chemical library, NSC-87877 and NSC-117199 have been identified as Shp2 PTP inhibitors. Signif
