95305-51-4

Basic information

• Product Name: L-Glutamic acid, N-[(4-methylphenyl)sulfonyl]-, dimethyl ester
• CAS NO: 95305-51-4
• Molecular Formula: C14H19NO6S
• Molecular Weight: 329.374
• Mol File: 95305-51-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[(4-methylphenyl)sulfonyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[(4-methylphenyl)sulfonyl]-, dimethyl ester(95305-51-4)
• EPA Substance Registry System: L-Glutamic acid, N-[(4-methylphenyl)sulfonyl]-, dimethyl ester(95305-51-4)

Safety Data

• Hazardous Substances Data: 95305-51-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 4816-80-2 N-tosyl-L-glutamic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 23150-65-4 L-glutamic dimethyl ester hydrochloride 
• 42749-49-5 N²-<(4-methylphenyl)sulfonyl>-L-glutamine 
• 500143-69-1 dimethyl (2S)-2-{N-[(tert-butoxy)carbonyl]-(4-methylphenyl)sulfonylamino}pentane-1,5-dioate 
• 56-86-0 L-glutamic acid 

Downstream Products

• 67488-65-7 (S)-methyl 1-tosylpyrrolidine-2-carboxylate 
• 934588-74-6 N-((1S)-4-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-1-[((2S)-5-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide 
• 934588-76-8 (4S)-4-[(4-methylphenyl)sulfonyl]amino-5-[((2S)-[(4-methylphenyl)sulfonyl]amino-5-[(4-methylphenyl)sulfonyl]oxypentyl)disulfanyl]pentyl 4-methylbenzenesulfonate 
• 934588-75-7 N-((1S)-4-hydroxy-1-[((2S)-5-hydroxy-2-[(4-methylphenyl)sulfonyl]aminopentyl)disulfanyl]methylbutyl)-4-methyl-1-benzenesulfonamide 
• 934588-72-4 N-[(1S)-4-(1-tert-butyl-1,1-diphenylsilyl)oxy-1-(hydroxymethyl)butyl]-4-methyl-1-benzenesulfonamide 
• 934588-73-5 (2S)-2-[3-(1-tert-butyl-1,1-diphenylsilyl)oxypropyl]-1-[(4-methylphenyl)sulfonyl]azirane 
• 500143-69-1 dimethyl (2S)-2-{N-[(tert-butoxy)carbonyl]-(4-methylphenyl)sulfonylamino}pentane-1,5-dioate 
• 934588-71-3 N-(4-hydroxy-1-hydroxymethyl-butyl)-4-methyl-benzenesulfonamide 

Relevant articles and documents

Synthesis, Characterization, and Reactivity of an Ethynyl Benziodoxolone (EBX)-Acetonitrile Complex

The synthesis of a crystalline ethynyl-1,2-benziodoxol-3(1H)-one (EBX)-acetonitrile complex is described. EBX has been widely used as an active species for a variety of reactions; however, its high instability has so far prevented its isolation. The EBX-acetonitrile is self-assembled into a double-layered honeycomb structure through weak hypervalent iodine secondary interactions and hydrogen bonding. The N-ethynylation of a variety of sulfonamides using the EBX-acetonitrile complex as a substrate under mild conditions is also described.

Regio- and stereospecific synthesis of β-sulfonamidodisulfides and β-sulfonamidosulfides from aziridines using tetrathiomolybdate as a sulfur transfer reagent

A comprehensive study of a general and effective one-step procedure for the synthesis of β-sulfonamidodisulfides directly from N-tosyl aziridines in a regio- and stereospecific manner under neutral conditions without the use of any Lewis acid or base has been reported. This methodology is extended to the synthesis of an optically pure cyclic seven-membered disulfide 29. Synthesis of a variety of β-sulfonamidosulfides involving tandem, multistep reactions in one pot is also reported.

A new selective cleavage of N,N-dicarbamoyl-protected amines using lithium bromide

A mild and new procedure for the selective cleavage of an alkoxycarbonyl group (Boc, CBz) in N,N-dicarbamoyl-protected amino compounds is described. The method is based on the use of lithium bromide in acetonitrile and is compatible with a large range of other functionalities present in the substrates. Compared with other reported methodologies, the procedure is particularly useful for the Cbz-selective cleavage in N,N-Ts,Cbz-diprotected amines. A rationalization of the selectivity supported by ab initio calculations is also presented.