95314-82-2

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 55, p. 1125, 1990 DOI: 10.1021/jo00290a064

Upstream product

• 455-16-3 p-toluenesulfonyl fluoride 
• 105-37-3 Ethyl propionate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 535-11-5 Ethyl 2-bromopropionate 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 609-14-3 2-acetylpropanoic acid ethyl ester 

Downstream Products

• 67275-03-0 ethyl 2,3-dimethyl-3-nitro-2-tosylbutanoate 
• 77218-65-6 ethyl 2,3-dimethyl-3-nitro-2-tosylpentanoate 
• 257613-76-6 ethyl 2-(phenylseleno)-2-(p-toluenesulfonyl)propanate 
• 1136834-43-9 C₁₈H₂₀O₄S 
• 134993-72-9 ethyl 2-(p-toluenesulfonyl)acrylate 

Relevant academic research and scientific papers

An efficient electrochemical synthesis of β-keto sulfones from sulfinates and 1,3-dicarbonyl compounds

An efficient electrochemical synthesis of β-keto sulfones from sulfinates and 1,3-dicarbonyl compounds has been developed. The present electrochemical route could afford the target products in high to excellent yields under mild conditions.

[2 + 1] Cycloaddition Reactions of a 1-Seleno-2-silylethene to 2-Sulfonylacrylates: Stereoselective Synthesis of Sulfone-Substituted Cyclopropanes

Reaction of 1-(phenylseleno)-2-(trimethylsilyl)ethene 1 and methyl or ethyl 2-p-toluene- or benzene-sulfonylacrylates 3 in the presence of SnCl4 at -78°C gave sulfone-substituted cyclopropanes 4 as single stereoisomers. The structure of one of these crystalline cyclopropane products was elucidated by X-ray crystallographic analysis. The relative stereochemistry of the cyclopropane ring carbon (C2) and selenosilylmethyl group was determined as R,R and S,S, which is consistent with previous mechanical considerations and the NOE determination. 2-Sulfinyl acrylate 2 did not undergo this cycloaddition. The difference in reactivity of the sulfoxide 2 and sulfones 3 toward 1 was explained by comparison of LUMO levels of 2-SnCl4 and 3-SnCl4 complexes and activation energies in the synclinal addition of 1 to the complexes.

Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds

This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments or atherosclerosis.