95331-76-3

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-N-ISOBUTYLACETAMIDE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs.
Used in Agrochemical Industry:
2-BROMO-N-ISOBUTYLACETAMIDE is used as an intermediate in the synthesis of agrochemicals, playing a role in the creation of new compounds for agricultural applications.
Used in Medicinal Chemistry and Drug Discovery:
2-BROMO-N-ISOBUTYLACETAMIDE is used as a potential reagent in medicinal chemistry and drug discovery due to its structural properties and reactivity, which may contribute to the development of novel chemical compounds for various applications.
Used in Industrial Applications:
2-BROMO-N-ISOBUTYLACETAMIDE has potential applications in various industrial fields, as its synthesis and properties make it a valuable compound in the development of new chemical products and applications.

InChI:InChI=1/C6H12BrNO/c1-5(2)4-8-6(9)3-7/h5H,3-4H2,1-2H3,(H,8,9)

Upstream product

• 78-81-9 isobutylamine 
• 598-21-0 2-Bromoacetyl bromide 
• 79-08-3 bromoacetic acid 
• 22118-09-8 2-bromoacetyl chloride 

Downstream Products

• 66110-12-1 (2E,4E)-N-isobutyl-5-phenylpenta-2,4-dienamide 
• 861929-74-0 Bis(phenylmethyl) 4,10-bis[2-[(2-methylpropyl)amino]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate 
• 504-48-3 spilanthol 
• 99564-68-8 (E)-N-isobutyl-3-(p-tolyl)acrylamide 
• 119826-64-1 4-Methoxy-N-isobutyl-zimtsaeureamid 
• 92449-52-0 N-isobutyl-(E)-cinnamamide 
• 113449-26-6 4-Chlor-N-isobutyl-zimtsaeureamid 
• 110890-35-2 [2-[(2-methylpropyl)amino]-2-oxoethyl]triphenylphosphonium bromide 
• 62826-50-0 isobutyl triphenylphosphonium acetamide 
• 99564-53-1 N-i-butyl-3-(4-nitrophenyl)-2E-propenamide 

Relevant academic research and scientific papers

Microwave-assisted synthesis of N -isobutyl-4,5-epoxy-2(E)-decenamide

A new and efficient synthesis of a naturally occurring amide alkaloid, N-isobutyl-4,5-epoxy-2(E)-decenamide isolated from the roots of Piper nigrum has been described involving a total of nine steps. Octanal and 2-bromoacetic acid have been used as the starting materials.

Polyunsaturated alkyl amides from echinacea: Synthesis of diynes, enynes, and dienes

The synthesis of 20 alkyl amides, including 15 naturally occurring polyunsaturated alkyl amides previously identified from Echinacea spp. (1-13 and 62) or from Achilla sp. (55) and five previously unknown geometric isomers (23, 28, 67, 73, and 80), is described. Importantly, these amides include all of the major alkyl amides present in commercially used Echinacea extracts. The syntheses demonstrate methodology used for constructing alkyl amides containing conjugated diyne and isomerically pure enyne and diene moieties and may be adapted easily for the preparation of other alkyl amides present in Echinacea spp. Terminal-conjugated diynes were prepared by a Cadiot-Chodkiewitz coupling/deprotection sequence utilizing a protected bromoacetylene, and methyl-substituted diynes were made via a base-catalyzed rearrangement of terminal-skipped diynes. Conjugated dienes were prepared conveniently and with high stereoselectivity by the reduction of enynes or diynes with Rieke zinc. With the exception of 1-2 and 11-12, the alkyl amides are synthesized here for the first time, and their NMR data are consistent with that of the reported isolated natural compounds.

Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus

The first step in HIV infection is the binding of the envelope glycoprotein gp120 to the host cell receptor CD4. An interfacial "Phe43 cavity" in gp120, adjacent to residue Phe43 of gp120-bound CD4, has been suggested as a potential target for therapeutic intervention. We designed a CD4 mutant (D1D2F43C) for site-specific coupling of compounds for screening against the cavity. Altogether, 81 cysteine-reactive compounds were designed, synthesized, and tested. Eight derivatives exceeded the affinity of native D1D2 for gp120. Structure-activity relationships (SAR) for derivatized CD4 binding to gp120 revealed significant plasticity of the Phe43 cavity and a narrow entrance. The primary contacts for compound recognition inside the cavity were found to be van der Waals interactions, whereas hydrophilic interactions were detected in the entrance. This first SAR on ligand binding to an interior cavity of gp120 may provide a starting point for structure-based assembly of small molecules targeting gp120-CD4 interaction.

Modulation of the lifetime of water bound to lanthanide metal ions in complexes with ligands derived from 1,4,7,10-tetraazacyclododecane tetraacetate (DOTA)

A series of di- and tetraamide derivatives of DOTA were synthesized, and their lanthanide(III) complexes were examined by multinuclear 1H-, 13C-, and 17O-NMR spectroscopy, and compared with literature data of similar, know