953393-41-4Relevant academic research and scientific papers
A turn-on fluorescent indicator for citrate with micromolar sensitivity
Burguete, M. Isabel,Galindo, Francisco,Luis, Santiago V.,Vigara, Laura
, p. 4027 - 4033 (2007)
A turn-on fluorescent indicator for citric acid (citrate) has been developed, displaying high emission enhancement (+1500%) and low interference by other carboxylates. The sensor is based on the non-emissive copper(ii) complex of a fluorescent amino amide, which, upon addition of citrate decomplexates to yield the emissive ligand. The detection limit estimated for this new chemosensing system is about 0.5 M. This novel approach to the analysis of citrate constitutes an alternative ca. 102-103 times more sensitive than the standard method based on the enzyme citrate lyase. The Royal Society of Chemistry.
Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides
Escorihuela, Jorge,Burguete, M. Isabel,Luis, Santiago V.
scheme or table, p. 6885 - 6888 (2009/04/07)
A series of α-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac)2 catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process.
Nickel complexes from α-amino amides as efficient catalysts for the enantioselective Et2Zn addition to benzaldehyde
Burguete, M. Isabel,Collado, Manuel,Escorihuela, Jorge,Galindo, Francisco,García-Verdugo, Eduardo,Luis, Santiago V.,Vicent, María J.
, p. 6891 - 6894 (2007/10/03)
Ni2+ complexes derived from simple α-amino amides catalyze very efficiently the addition of Et2Zn to benzaldehyde, giving (S)-1-phenylethanol as the major isomer in most cases (94% yield, 97% ee for R=Bn). The nature of the substituent on the amide nitrogen atom seems to play a key role in determining the asymmetric induction observed.
