953395-50-1

Upstream product

• 953395-49-8 6''-(2,4,6-triisopropylbenzenesulfonyl)-1,3,6',3''-tetra-N-(tert-butoxycarbonyl)kanamycin A 
• 80860-34-0 di-tert-butyl ((1S,3R,4S,5R,6R)-4-(((2S,3R,4S,5S,6R)-4-((tert-butoxycarbonyl)amino)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,4S,5S,6R)-6-(((tert-butoxycarbonyl)amino)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-5-hydroxycyclohexane-1,3-diyl)dicarbamate 
• 3847-27-6 Kanamycin A sulfate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 59-01-8 kanamycin A 

Downstream Products

• 1134204-89-9 Fmoc-Trp(Boc)-β-alanyl-4-[[1,2,3]-triazol-1-yl-[(1,3,6',3''-tetra-N-(tert-butoxycarbonyl)-6''-deoxykanamycin)-6'']-(4-β-alanyl-4-[1,2,3]-triazol-1-yl-1,3,6',3''-tetra-N-(tert-butoxycarbonyl)-6''-deoxykanamycin)-6'']-Trp(Boc)-NHBn 
• 1134204-80-0 1,3,6',3''-tetra-N-(tert-butoxycarbonyl)-6''-deoxy-6''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-kanamycin 
• 1134204-79-7 1,3,6',3''-tetra-N-(tert-butoxycarbonyl)-6''-deoxy-6''-(4-(β-alanyl(Fmoc)-Val-Gly-OtBu)-[1,2,3]-triazol-1-yl)-kanamycin 
• 1203669-89-9 1,3,6',3''-tetra-N-(tert-butoxycarbonyl)-6''-amino-6''-deoxy-kanamycin A 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION

The present invention provides compounds, compositions thereof, and methods of using the same.

Rapid solid-phase syntheses of a peptidic-aminoglycoside library

A library of mono- and di-amino acid peptidic-aminoglycosides (PAs), with kanamycin and neomycin as the model aminoglycosides, was systematically and rapidly synthesized via solid phase peptide synthesis. Aminoglycosides were first converted into N-Boc pr

COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES

The present invention provides compounds, compositions thereof, and methods of using the same.

GUANIDINYLATED AMINOGLYCOSIDE-LIPID CONJUGATES

Guanadinylated aminoglycoside-lipid conjugates are prepared. Such conjugates may comprise an aminoglycoside such as an aminoglyucoside antibiotic like neomycin or kanamycin, at least one guanidino group attached to a primary or secondary carbon atom of the aminoglyucoside group and at least one lipid group attached through a bond or a linker to a branched carbon atom of the aminoglycoside. These conjugates exhibit improve antibacterial activity and may be used in conjunction with another antibiotic.