95342-41-9

Upstream product

• 68546-28-1 camphor 
• 104-87-0 4-methyl-benzaldehyde 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 473929-46-3 (1R,4R)-3-[(E)-(dimethylamino)methylidene]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 
• 589-18-4 4-Methylbenzyl alcohol 
• 464-48-2 (1S)-camphor 
• 464-43-7 d-borneol 

Relevant academic research and scientific papers

New Second-Order Nonlinear Optical Materials with a Cutoff Wavelength of 350 nm. 3-Benzylidene-D-camphor Derivatives

A series of 3-benzylidene-D-camphor derivatives has been synthesized in order to examine the second-harmonic generation (SHG) efficiency along with the transparent wavelength region.Through reflection powder measurement, 3-cinnamylidene-D-camphor having a cutoff wavelength of 350 nm, shows the efficiency 10 times as large as that of urea.

Novel camphor-based pyrimidine derivatives induced cancer cell death through a ROS-mediated mitochondrial apoptosis pathway

A series of novel camphor-based pyrimidine derivatives (3a-3x) have been synthesized; their structures were determined by using conventional methods and compound 3f was further confirmed through single crystal XRD analysis. The cytotoxic activity of the target compounds against a panel of human normal (GES-1) and cancer cell lines (MDA-MB-231, RPMI-8226, A549) was evaluated by MTS assay. Here we found that compound 3f exhibited the strongest anti-tumor activity, comparable to that of etoposide, and had much lower cytotoxicity to normal GES-1 cells (IC50 > 50 μM) than the reference drug (IC50 = 8.89 μM). Subsequent mechanism studies in MDA-MB-231 cells revealed that compound 3f caused G0/G1 phase arrest and apoptosis in a dose dependent manner. Moreover, the loss of mitochondrial membrane potential and enhancement of cellular ROS levels were also observed upon 3f treatment, which indicated that 3f exerted cytotoxic activity by a ROS-mediated mitochondrial apoptosis pathway. This result was confirmed by a significant increase in the expression of pro-apoptotic proteins Bax, cytochrome C and caspase-3, and downregulation of anti-apoptosis protein Bcl-2. Overall, 3f can be adopted for further investigation in the development of antitumor agents based on natural products.

Immobilization and continuous recycling of photoredox catalysts in ionic liquids for applications in batch reactions and flow systems: Catalytic alkene isomerization by using visible light

A catalytic (E)- to (Z)-isomerization of olefins using a photoredox catalyst under mild reaction conditions is presented. A variety of (Z)-alkenes can be prepared in the presence of visible light. A new reaction system allows an easy and efficient scale-up, as well as a continuous flow process in which the photocatalyst is immobilized in an ionic liquid and continuously recycled by simple phase separation. Catalytic (E)- to (Z)-isomerizations of olefins under mild conditions can be achieved by use of a photosensitizer and visible light. A new reaction system such as depicted allows an easy and efficient scale-up, as well as continuous flow processes in which the photocatalyst is immobilized in an ionic liquid and continuously recycled by phase separation.

COSMETIC TREATMENT METHOD USING A COMPOUND THAT CAN BE CONDENSED IN SITU AND A UV-RADIATION-FILTERING AGENT

The present invention relates to a method for the cosmetic treatment of the skin, comprising the application, to the skin: of a compound or group of compounds A capable of condensing in situ and exhibiting at least one reactive functional group FA which is free after condensation; and of a screening agent C which screens out UV radiation, comprising a reactive functional group FC capable of forming a covalent bond or a physical (ionic, hydrogen) bond by reaction with the functional group FA.

Photoprotective compositions comprising photosensitive 1,3,5-triazine compounds, dibenzoylmethane compounds and siliceous s-triazines substituted with two aminobenzoate or aminobenzamide groups

UV-photoprotective, topically applicable cosmetic/dermatological compositions contain: (a) at least one dibenzoylmethane compound,(b) at least one 1,3,5-triazine compound that is photosensitive in the presence of a dibenzoylmethane compound, and(c) at least one siliceous s-triazine compound substituted with two aminobenzoate or aminobenzamide groups, or a tautomeric form thereof, the 1,3,5-triazine compounds being improvedly photostable in such compositions.

Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor

Cosmetic/sunscreen compositions contain a combination of at least one dibenzoylmethane sunscreen compound and a photostabilizing amount of at least one dithiolane compound of formula (I) below:

Cosmetic compositions comprising photostabilized dibenzoylmethane compounds and 2-pyrrolidinone-4- carboxy esters

Photostable cosmetic compositions contain, formulated into a cosmetically acceptable vehicle, at least one UV-screening system that includes: (a) at least one dibenzoylmethane compound, and(b) at least one 2-pyrrolidinone-4-carboxy ester compound having the following formula (I): in which: R1 is a linear or branched C1-C20 alkyl radical, andR2 is a linear or branched C1-C20 alkyl radical which optionally includes a C5-C6 ring member, the phenyl radical, the benzyl radical or the phenethyl radical.

COSMETIC AND/OR DERMATOLOGICAL COMPOSITION BASED ON N,N'-DIARYLMETHYLENEETHYLENEDIAMINEDIACETIC ACID ESTER(S)

The present invention relates to a cosmetic and/or dermatological composition comprising, in a physiologically acceptable medium containing at least one oil: (a) at least one compound of general formula (Ia): and (b) an efficient amount of at least one solvent chosen from: (i) isononyl isononanoate;(ii) dimethyl isosorbide;(iii) the amino acid esters of formula (II): [in-line-formulae]R′1(CO)N(R′2)CH(R′3)(CH2)n(CO)OR′4??(II)[/in-line-formulae](iv) and a mixture thereof.

Aqueous fluid photoprotective compositions comprising tertiary-amide-terminated polyamide polymers

Topically applicable, fluid anti-sun/sunscreen compositions useful for protecting the skin and/or the hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective system for screening out UV radiation; and(b) at least one tertiary-amide-terminated polyamide (ATPA) polymer, formulated into a topically applicable, cosmetically acceptable aqueous support therefor; the subject anti-sun/sunscreen compositions are especially provided as sprays, notably for the purpose of increasing the sun protection factor (SPF) and/or of reducing or even eliminating the fluffing effect thereof.

COMPOSITION CONTAINING A PHENANTHRENOL

Novel uses of phenanthrenol compounds for improving the appearance and/or texture of the skin.