953786-65-7

Upstream product

• 953786-60-2 (S)-2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-1-((3R,5S)-5-tert-butyldimethylsilyloxy-3-(triethylsilyloxy)cyclopent-1-enyl)-1-chloroethane 
• 178034-12-3 (1S,4R)-4-hydroxycyclopent-2-enyl 2,2,2-trimethylacetate 
• 953786-54-4 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide 
• 953786-52-2 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde 
• 953786-59-9 (R)-2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-1-((3R,5S)-5-tert-butyldimethylsilyloxy-3-(triethylsilyloxy)cyclopent-1-enyl)ethanol 
• 953786-58-8 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-1-((3R,5S)-5-tert-butyldimethylsilyloxy-3-(triethylsilyloxy)cyclopent-1-enyl)ethanone 
• 953786-57-7 (1S,4R)-1-(tert-butyldimethylsilyloxy)-4-(triethylsilyloxy)-2-iodocyclopent-2-ene 
• 953786-56-6 (R)-4-(triethylsilyloxy)-2-iodocyclopent-2-enone 
• 111057-12-6 (R)-4-(triethylsilyloxy)-cyclopent-2-enone 
• 953786-55-5 (1S,4R)-4-(triethylsilyloxy)cyclopent-2-enol 
• 953786-63-5 (1S,4R)-4-(triethylsilyloxy)cyclopent-2-enyl pivalate 
• 909766-98-9 4-benzyloxy-6-iodo-2,3-dimethoxybenzaldehyde 

Downstream Products

• 953786-50-0 (S)-3-((S)-2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-1-chloroethyl)-4-(tert-butyldimethylsilyloxy)cyclopent-2-enone 

Relevant academic research and scientific papers

Enantioselective total synthesis of (-)-acutumine

(Chemical Equation Presented) An account of the total synthesis of the tetracyclic alkaloid (-)-acutumine is presented. A first-generation approach to the spirocyclic subunit was unsuccessful as a result of incorrect regioselectivity in a radical cyclizat

Synthesis of the acutumine spirocycle via a radical-polar crossover reaction

A new radical-polar crossover reaction was developed that consists of intramolecular conjugate addition of an aryl radical followed by enolate formation and hydroxylation. A C-C bond, a C-O bond, and two congested stereocenters are created in the process.