954237-79-7

Basic information

• Product Name: methyl 2-{[2-(3,4-dihydroxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate
• Synonyms: methyl 2-{[2-(3,4-dihydroxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate
• CAS NO: 954237-79-7
• Molecular Weight: 376.371
• Mol File: 954237-79-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-{[2-(3,4-dihydroxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-{[2-(3,4-dihydroxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate(954237-79-7)
• EPA Substance Registry System: methyl 2-{[2-(3,4-dihydroxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate(954237-79-7)

Safety Data

• Hazardous Substances Data: 954237-79-7(Hazardous Substances Data)

Upstream product

• 109-12-6 2-aminopyrimidine 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 66715-31-9 o-methoxycarbonylphenylisonitrile 

Relevant articles and documents

First example of the Groebke MCR using hydoxybenzaldehydes and substituted 2-aminopyrimidines

(Chemical Equation Presented) A three component condensation of 2-aminopyrimidines, isocyanides and 4-hydroxybenzaldehydes was studied. 3-Amino-2-(4-hydroxyphenyl)imidazo[1,2-a]pyrimidine derivatives were obtained in moderate yields. Using 4-hydroxy-3,5-dimethoxybenzaldehyde and 2-aminopyrimidine as starting materials in the condensation led to mixtures of isomeric 2- and 3-aminoimidazo[1,2-a]pyrimidines. It was demonstrated, that the regiospecificity of this reaction is mainly defined by the steric hindrance of substituents on the pyrimidine nucleus and the carbonyl activity of the corresponding aldehydes.