66715-31-9

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 109-94-4 formic acid ethyl ester 
• 79-22-1 methyl chloroformate 
• 183209-26-9 ortho-bromophenyl isocyanide 
• 41270-80-8 N-formylanthranilic acid methyl ester 

Downstream Products

• 944777-18-8 methyl 2-{[2-(4-hydroxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate 
• 946762-66-9 methyl 2-{[2-(4-hydroxy-3-methoxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate 
• 954237-79-7 methyl 2-{[2-(3,4-dihydroxyphenyl)imidazo[1,2-a]pyrimidin-3-yl]amino}benzoate 
• 946730-98-9 methyl 2-{[2-(4-hydroxy-3-methoxyphenyl)-5,7-dimethylimidazo[1,2-a]pyrimidin-3-yl]amino}benzoate 
• 106283-19-6 (S)-2-(2-(2-(2-(dimethylamino)benzamido)-N-methylacetamido)-3-methylbutanamido)benzoic acid 
• 1418290-30-8 2-(2-(2-(2-(dimethylamino)benzamido)-N-propylacetamido)-3-methylbutan-amido)benzoic acid 
• 1418290-31-9 2-(2-(N-benzyl-2-(2-(dimethylamino)benzamido)acetamido)-3-methylbutanamido)benzoic acid 
• 1418290-32-0 2-(2-(2-(2-(dimethylamino)benzamido)-N-(4-fluorobenzyl)acetamido)-3-methylbutanamido)benzoic acid 
• 1418290-33-1 2-(2-(N-(4-chlorobenzyl)-2-(2-(dimethylamino)benzamido)acetamido)-3-methylbutanamido)benzoic acid 
• 1418290-34-2 2-(2-(2-(2-(dimethylamino)benzamido)-N-phenethylacetamido)-3-methylbutanamido)benzoic acid 
• 1418290-22-8 methyl 2-(2-(2-(2-(dimethylamino)benzamido)-N-methylacetamido)-3-methyl-butanamido)benzoate 
• 1418290-25-1 methyl 2-(2-(2-(2-(dimethylamino)benzamido)-N-propylacetamido)-3-methyl-butanamido)benzoate 
• 1418290-26-2 methyl 2-(2-(N-benzyl-2-(2-(dimethylamino)benzamido)acetamido)-3-methylbutanamido)benzoate 
• 1418290-27-3 methyl 2-(2-(2-(2-(dimethylamino)benzamido)-N-(4-fluorobenzyl)acetamido)-3-methylbutanamido)benzoate 

Relevant academic research and scientific papers

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.

The multicomponent approach to N-methyl peptides: Total synthesis of antibacterial (-)-viridic acid and analogues

Two syntheses of natural viridic acid, an unusual triply N-methylated peptide with two anthranilate units, are presented. The first one is based on peptide-coupling strategies and affords the optically active natural product in 20% overall yield over six steps. A more economical approach with only four steps leads to the similarly active racemate by utilizing a Ugi four-component reaction (Ugi-4CR) as the key transformation. A small library of viridic acid analogues is readily available to provide first SAR insight. The biological activities of the natural product and its derivatives against the Gram-negative bacterium Aliivibrio fischeri were evaluated.

Synthesis of tetrazolodiazepines by a five-centered four-component azide Ugi reaction. Scope and limitations

Tetrazolo[1,5-a][1,4]benzodiazepines were obtained by an efficient azide five-centered four-component Ugi reaction, which used ketones, sodium azide, ammonium chloride, and the corresponding isonitrile. Scope and limitations of this multi-component reaction were considered.

ortho-Lithiophenyl isocyanide: A versatile precursor for 3H-quinazolin-4-ones and 3H-quinazolin-4-thiones

(Chemical Equation Presented) ortho-Lithiophenyl isocyanide has been generated from ortho-bromophenyl isocyanide and successfully employed toward the synthesis of 2-substituted phenyl Isocyanides as well as 2,3-disubstituted 3H-quinazoline-4-ones and 3H-q

Synthesis of 4-hydroxy-3-quinolinecarboxylic acid derivatives by a condensation/cyclization sequence between o-isocyanobenzoates and magnesium enolates

Addition of magnesium ester and amide enolates, generated using an excess amount of a magnesium amide (from diisopropylamine and ethylmagnesium bromide), to o-isocyanobenzoates affords 4-hydroxy-3-quinolinecarboxylic esters and amides by a tandem Claisen-type condensation/cyclization sequence.