954239-52-2

Usage

Uses

Used in Pharmaceutical Industry:
3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID METHYL ESTER is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID METHYL ESTER serves as a building block for the development of new drug candidates, leveraging its unique reactivity to form novel compounds with potential medicinal properties.
Used in Drug Development:
3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID METHYL ESTER is utilized in drug development processes to create advanced molecular entities that can be further optimized for efficacy, safety, and pharmacokinetic properties in the treatment of various diseases and conditions.

Upstream product

• 67-56-1 methanol 
• 675109-26-9 6-bromo-1-oxo-2,3-dihydro-1H-isoindole 
• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

ASK1 INHIBITOR COMPOUNDS AND USES THEREOF

Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non

Convenient access to isoindolinones via carbamoyl radical cyclization. Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products

An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical cyclization process from stable carbamoylxanthates, derived from secondary tert-butylamines, is described. The proposed mechanism for this transformation involves, the generation of a carbamoyl radical, its cyclization to the aromatic system, and the dilauroyl peroxide (DLP) mediated rearomatization to generate the isoindolinone ring system. Additionally, the syntheses of cichorine and 4-hydroxyisoindolin-1-one natural products were carried out to underscore the synthetic potential of this xanthate-based carbamoyl radical-oxidative cyclization.

Carbamoyl radicals from carbamoylxanthates: a facile entry into isoindolin-1-ones

It has been found that carbamoylxanthates derived from secondary t-butyl amines are stable compounds which function as efficient sources of carbamoyl radicals. The carbamoylxanthates derived from t-butylbenzylamines can be efficiently transformed into 2-t