954272-07-2

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 121-89-1 3-Nitroacetophenone 

Downstream Products

• 1350523-39-5 rac-2-amino-2-(3-nitro-phenyl)-propionic acid methyl ester 
• 1350523-60-2 C₁₉H₁₈N₆O₂ 
• 1350523-59-9 rac-5-chloropyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide 
• 1350523-43-1 rac-5-amino-3-(3-aminophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 
• 1350523-42-0 rac-5-amino-1,3-dimethyl-3-(3-nitrophenyl)-3,6-dihydro-1H-pyrazin-2-one 
• 1350523-75-9 rac-N-[2-tert-butoxycarbonylamino-2-(3-nitro-phenyl)-propyl]-N-methyl-oxalamic acid ethyl ester 
• 1350523-41-9 rac-1,3-dimethyl-3-(3-nitrophenyl)-5-thioxopiperazine-2-one 
• 1350523-73-7 rac-[2-hydroxy-1-methyl-1-(3-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 1350523-40-8 rac-1,3-dimethyl-3-(3-nitrophenyl)piperazine-2,5-dione 
• 1350523-71-5 2-(2-chloroacetylamino)-2-(3-nitrophenyl)propionic acid methyl ester 
• 1350523-63-5 C₁₈H₁₈ClN₅O₂ 
• 1350523-64-6 C₁₈H₁₈ClN₅O₂ 
• 1350523-50-0 rac-5-chloro-pyridine-2-carboxylic acid[3-(6-amino-2,4-dimethyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-phenyl]-amide 
• 1350523-49-7 rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one 

Relevant academic research and scientific papers

3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER FORMS OF DEMENTIA

The present invention relates to novel 3-amino-5,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical com

3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER?S DISEASE AND OTHER FORMS OF DEMENTIA

The present invention relates to novel 3-amino-5,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical com

Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors

Aminopiperazinone inhibitors of BACE were identified by rational design. Structure based design guided idea prioritization and initial racemic hit 18a showed good activity. Modification in decoration and chiral separation resulted in the 40 nM inhibitor,

5-AMINO-3,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 5-amino-3,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical com