954373-41-2Relevant academic research and scientific papers
Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: Synthesis, biological evaluation, and ligand-based pharmacophore identification
Su, Bin,Tian, Ran,Darby, Michael V.,Brueggemeier, Robert W.
, p. 1126 - 1135 (2008)
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment of estrogen receptor positive breast cancer. Previously, the COX-2 selective inhibitor nimesulide and analogs decreased aromatase expression and enzyme acti
