954418-33-8

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 100-52-7 benzaldehyde 
• 126-81-8 dimedone 

Relevant academic research and scientific papers

Facile and efficient synthesis of tetrahydrobenzimidazo [2,1-b]quinazolin-1(2h)-one derivatives using br?nsted acidic ionic liquid immobilized on nanoporous Na+-montmorillonite

In this work, an efficient and green procedure have been described for the synthesis of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H-one derivatives using nanoporous sodium montmorillonite clay (Na+-MMT) modified with 1-methyl-3-(trimethoxysilyl

An Efficient, Green, and Solvent-free Multi-component Synthesis of Benzimidazolo/Benzothiazolo Quinazolinone Derivatives Using Sc (OTf)3 Catalyst Under Controlled Microwave Irradiation

An efficient, fast, and green synthesis of benzimidazolo/benzothiazolo quinazolinone derivatives has been developed under solvent-free conditions by the reaction of 2-aminobenzimidazole/2-aminobenzothiazole, aromatic aldehydes, and 1,3-diketones. This method extended the application of microwave irradiation and scandium triflate combination and also tenders a lot of benefits such as excellent product yields, shorter reaction time, easy isolation of products, and environmentally benign reaction conditions.

Green and highly efficient MCR strategy for the synthesis of pyrimidine analogs in water via C–C and C–N bond formation and docking studies

The current study deals with the synthesis of some novel pyrimidine derivatives by the reaction of aromatic aldehydes, 2-aminobenzothiazole, and dimedone in the presence of thiamine hydrochloride (VB1) as an organocatalyst. The use of VB1 as a catalyst has eradicated the peril of metal contamination in the products that is viable for eco-friendly pathways and proven to be a better catalyst under sustainable conditions. The mechanism of the reaction involved Knoevenagel condensation followed by Michael addition. The designed protocol has many fascinating features, viz. high product yields, eco-friendly, milder reaction conditions, avoiding the use of hazardous solvent, and easily recoverable and reusable catalyst. The good functional group tolerance with a series of derivatives has been demonstrated. Molecular docking studies were performed on the synthesized compounds using Staphylococcus aureus dihydropteroate synthase (saDHPS) (6CLV) and DNA gyrase (1KZN) proteins. Furthermore, the binding mode of the ligands with the protein study was quite promising. Among the synthesized compounds, compound 5e was found to be the most potent and showed good binding interactions and the highest docking score against both proteins, 1KZN and 6CLV. Graphical abstract: [Figure not available: see fulltext.]

Multicomponent reaction-based discovery of pyrimido[2,1-b][1,3]benzothiazole (PBT) as a novel core for full-color-tunable AIEgens

The Hf(OTf)4-catalyzed three-component reaction (3CR) was employed as a powerful tool for facile access to a library of 23 pyrimido[2,1-b][1,3]benzothiazole (PBT)-based AIEgens with full-color tunability, solid-state fluorescence quantum yields

Synthesis, characterization and catalytic application of tributyl(carboxymethyl)phosphonium bromotrichloroferrate as a new magnetic ionic liquid for the preparation of 2,3-dihydroquinazolin-4(1H)-ones and 4H-pyrimidobenzothiazoles

Abstract: In this paper, tributyl(carboxymethyl)phosphonium bromotrichloroferrate as a new magnetic ionic liquid bearing acetic acid tags was synthesized and characterized by several methods including Fourier transform infrared spectroscopy (FT-IR), energ

Preparation and characterization of Lewis acid grafted sulfonated carbon@titania composites for the multicomponent synthesis of 4H-pyrimido[2,1-b]benzothiazoles and benzoxanthenones under solvent-free conditions

A series of novel and highly efficient Lewis acids covalently grafted over sulfonic acid functionalized carbon@titania composites were successfully synthesized via sulfonation of carbon@titania composites followed by treatment with different Lewis acids l

Synthesis of benzimidazolo[2,3-b]quinazolinone derivatives via a one-pot multicomponent reaction promoted by a chitosan-based composite magnetic nanocatalyst

A practical and green approach for the one-pot multicomponent synthesis of tetraheterocyclic benzimidazolo[2,3-b]quinazolinones has been described via the condensation of 2-aminobenzimidazole or 2-aminobenzothiazole, dimedone, and various aldehydes using Fe3O4@chitosan as an environmentally benign and reusable nanocomposite catalyst in good to excellent yields.

Iron fluoride: The most efficient catalyst for one-pot synthesis of 4H-pyrimido[2,1-b]benzothiazoles under solvent-free conditions

A new iron fluoride assisted convenient and efficient strategy for the preparation of 4H-pyrimido[2,1-b]benzothiazoles derivatives in solvent-free media is described. The reactions can be performed at low-catalyst loadings with excellent functional group tolerance. The catalyst can be readily recovered and reused for next reaction for at least three runs without any significant impact on the yields of the products. The easy recovery of the catalyst and high yield of the products make the protocol attractive, sustainable, and economic.

Iron fluoride: The most efficient catalyst for one-pot synthesis of 4H-pyrimido[2,1-b]benzothiazoles under solvent-free conditions

A new iron fluoride assisted convenient and efficient strategy for the preparation of 4H-pyrimido[2,1-b]benzothiazoles derivatives in solvent-free media is described. The reactions can be performed at low-catalyst loadings with excellent functional group tolerance. The catalyst can be readily recovered and reused for next reaction for at least three runs without any significant impact on the yields of the products. The easy recovery of the catalyst and high yield of the products make the protocol attractive, sustainable, and economic.

Three-component synthesis of 4-amino-2-aryl-2H-pyrimido-[1,2-b][1,3] benzazole-3-carbonitriles and 4H-pyrimido-[2,1-b][1,3]benzazoles in the presence of magnesium oxide and 12-tungstophosphoric acid as catalysts

A simple and convenient approach was suggested for the synthesis of 4-amino-2-aryl-2H-pyrimido[1,2-b][1,3]benzimidazole-3-carbonitriles or -benzothiazole-3-carbonitriles through a three-component reaction of 2-aminobenzimidazole or 2-aminobenzothiazole, a