954525-03-2Relevant academic research and scientific papers
Copper-catalyzed tandem C-N bond formation reaction: Selective synthesis of 2-(trifluoromethyl)benzimidazoles
Chen, Mu-Wang,Zhang, Xing-Guo,Zhong, Ping,Hu, Mao-Lin
experimental part, p. 1431 - 1436 (2009/12/08)
A highly practical method for the synthesis of fluorinated benzimidazoles was developed by CuI/TMEDA-catalyzed cross-coupling reaction of N-(2-haloaryl)trifluoroacetimidoyl chlorides with primary amines. The present double amination process tolerates the
