1160967-80-5

Upstream product

• 615-43-0 2-iodophenylamine 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 1172590-78-1 1-(3-methoxyphenyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 1172590-79-2 1-(2-methoxyphenyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 321980-62-5 1-(4-chlorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 954525-03-2 1-(2-fluorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 954919-14-3 1-(4-methoxybenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 489425-63-0 1-(1-phenylethyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 478030-39-6 1-(4-fluorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 1172590-77-0 1-o-tolyl-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 134275-16-4 1-benzyl-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 478030-46-5 1-(2-chlorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 478030-37-4 1-(4-methylbenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 1235454-56-4 2-iodo-N-(1,1,1-trifluoro-4-(thiophen-2-yl)but-3-yn-2-ylidene)aniline 
• 1235454-55-3 N-(4-(4-chlorophenyl)-1,1,1-trifluorobut-3-yn-2-ylidene)-2-iodoaniline 
• 1235454-58-6 2-iodo-N-(1,1,1-trifluoro-5,5-dimethylhex-3-yn-2-ylidene)aniline 

Relevant academic research and scientific papers

Palladium-Catalyzed Carbonylative Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds

A procedure on palladium-catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2-(trifluoromethyl)quinazolin-4(3H)-ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale. (Figure presented.).

Palladium-Catalyzed Four-Component Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides, Propargyl Amines, and Diaryliodonium Salts: Access to Trifluoromethyl-Containing Trisubstituted Imidazoles

A palladium-catalyzed four-component carbonylative cyclization reaction for the expeditious construction of trifluoromethyl-containing trisubstituted imidazoles has been achieved. With readily accessible trifluoroacetimidoyl chlorides, propargyl amines, a

FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3 H)-ones from Isatins and Trifluoroacetimidoyl Chlorides

An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4(3H)-one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.

Copper-catalyzed thiolation annulations of 1,4-dihalides with sulfides leading to 2-trifluoromethyl benzothiophenes and benzothiazoles

Copper-catalyzed double thiolation reaction of 1,4-dihalides with sulfides has been developed for selectively synthesizing 2-trifluoromethyl benzothiophenes and benzothiazoles. In the presence of CuI, a variety of 2-halo-1-(2-haloaryl)-3,3,3-trifluoropropylenes smoothly underwent the thiolation annulation with Na2S to afford 2-trifluoromethyl benzothiophenes in moderate to good yields. Moreover, the conditions are compatible with N-(2-haloaryl)trifluoroacetimidoyl chlorides in the presence of NaHS and K3PO4, leading to 2-trifluoromethyl benzothiazoles.