1160967-80-5

Basic information

• Product Name: 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride
• Synonyms: 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride
• CAS NO: 1160967-80-5
• Molecular Weight: 333.479
• Mol File: 1160967-80-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride(1160967-80-5)
• EPA Substance Registry System: 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride(1160967-80-5)

Safety Data

• Hazardous Substances Data: 1160967-80-5(Hazardous Substances Data)

Upstream product

• 615-43-0 2-iodophenylamine 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 884069-49-2 1-p-tolyl-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 884069-61-8 1-(4-chlorophenyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 884069-78-7 1-(4-nitrophenyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 1172590-78-1 1-(3-methoxyphenyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 1172590-79-2 1-(2-methoxyphenyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 321980-62-5 1-(4-chlorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 954525-03-2 1-(2-fluorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 954919-14-3 1-(4-methoxybenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 489425-63-0 1-(1-phenylethyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 478030-39-6 1-(4-fluorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 1172590-77-0 1-o-tolyl-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 134275-16-4 1-benzyl-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 478030-46-5 1-(2-chlorobenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 478030-37-4 1-(4-methylbenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 

Relevant articles and documents

Palladium-Catalyzed Carbonylative Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds

A procedure on palladium-catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2-(trifluoromethyl)quinazolin-4(3H)-ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale. (Figure presented.).

FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3 H)-ones from Isatins and Trifluoroacetimidoyl Chlorides

An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4(3H)-one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.