95470-30-7Relevant academic research and scientific papers
HYBRID -IONONE AND CURCUMIN MOLECULES AS ANTICANCER AGENTS
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Page/Page column 39; 43, (2010/06/17)
The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesised and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breats cancer and lung cancer cell lines. Formulae (I), (II)
Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance
Zhou, Jinming,Geng, Guoyan,Shi, Qingwen,Sauriol, Francoise,Wu, Jian Hui
supporting information; experimental part, p. 5546 - 5550 (2010/03/02)
Incorporation of curcumin and β-ionone into one chemical entity led to identification of a novel antiandrogen with two bulky side chains, 6, which is a pure antagonist of the wild-type and the T877A, W741C, and H874Y mutated androgen receptors (AR), showi
