95480-31-2Relevant academic research and scientific papers
Synthesis, characterization, HOMO-LUMO study, and antimicrobial activity of organotin(IV) complexes of 4-piperidine carboxamide and its Schiff base
Rizwan, Muhammad,Ali, Saqib,Shahzadi, Saira,Sharma, Saroj K.,Qanungo, Kushal,Shahid, Muhammad,Mahmood, Sohail
, p. 341 - 351 (2014)
A series of organotin(IV) complexes has been synthesized by reacting 4-piperidine carboxamide with CS2 and R2SnCl 2/R3SnCl in 1: 1 M/L ratio at room temperature. The synthesized complexes were further treated with benzaldehyde to synthesize Schiff bases under stirring. All the complexes were characterized by elemental analysis, FT-IR, 1H and 13C NMR. FT-IR and semi-empirical study confirm the bidentate nature of ligand. The complexes exhibit four-coordinate geometry in solution. Thermodynamic parameters and molecular descriptors were calculated by using semi-empirical PM3 method. HOMO-LUMO calculations show that chlorodiorganotin complexes are more susceptible to nucleophilic attack when compared with triorganotin complexes. Negative heats of formation at 298 K demonstrate that 1, 4, and 7 are thermodynamically stable. The antimicrobial results have shown that complexes containing Schiff base exhibit significantly better activity compared to complexes with carboxamide derivatives. 2014
