955044-99-2Relevant academic research and scientific papers
Design, synthesis and cytotoxicity of chalcone analogs derived from 2-phenylimino-3-phenylthiazolidin-4-one
Satam, Vijay,Bandi, Ravi Kumar,Behera, Ajaya Kumar,Mishra, Bijay Kumar,Brockway, Olivia,Tzou, Samuel,Zeller, Matthias,Lee, Moses,Pati, Hari
experimental part, p. 704 - 708 (2012/04/05)
Eleven novel chalcone analogs having a 2-phenylimino-3-phenylthiazolidin-4- one core structure were designed, synthesized and investigated for cytotoxicity against murine B16 and L1210 cancer cells. Single crystal X-ray structure analyses confirmed that these chalcone analogs adopt a Z-geometry about the alkene bond. One of the compounds, 3j, which possesses a 2-chloro-5-bromo substitution in the phenyl moiety, showed moderate cytotoxicity against murine (B16) and human melanoma (MDA-MB-435) cell lines with an IC50 value of 57 and 12 μM, respectively. At 30 μM, compound 3j had virtually no effects on the microtubules in A10 cells.
