955084-69-2

Upstream product

• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 938182-43-5 5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 1226777-56-5 2-(3-bromophenyl)-5-(3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-1H-pyrazol-5-yl)-1,3,4-oxadiazole 
• 1339326-79-2 2-(3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-1H-pyrazol-5-yl)-5-((p-tolyloxy)methyl)-1,3,4-oxadiazole 
• 1339326-80-5 2-(3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-1H-pyrazol-5-yl)-5-((2-methoxyphenoxy)methyl)-1,3,4-oxadiazole 
• 1339326-81-6 2-(3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-1H-pyrazol-5-yl)-5-((4-chlorophenoxy)methyl)-1,3,4-oxadiazole 
• 1339326-82-7 2-(3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-1H-pyrazol-5-yl)-5-((2,4-dichlorophenoxy)methyl)-1,3,4-oxadiazole 
• 1339326-83-8 2-(3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-1H-pyrazol-5-yl)-5-((4-nitrophenoxy)methyl)-1,3,4-oxadiazole 
• 1197002-32-6 3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-N'-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-carbohydrazide 
• 1009091-14-8 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N'-[(1E)-(2-hydroxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazide 
• 1009091-15-9 C₂₄H₁₉Cl₂N₅O₂ 
• 1009091-13-7 C₂₄H₁₇Cl₂N₅O₃ 
• 1009091-16-0 C₂₁H₁₅Cl₂N₅O₂ 

Relevant academic research and scientific papers

Synthesis and biological validation of novel pyrazole derivatives with anticancer activity guided by 3D-QSAR analysis

Using literature data on anticancer activity of pyrazole derivatives, 3D-QSAR models were developed and 3D-QSAR analysis was performed. The 3D-QSAR analysis enabled identification of molecular properties that have the highest impact on antitumor activity against lung cancer cells. The results of 3D-QSAR analysis were taken into account while new compounds were designed. Obtained 3D-QSAR models were used for prediction of activity of new compounds. In this way, design of new compounds was guided by 3D-QSAR analysis which was performed on literature data. Ten new pyrazole derivatives were synthesised and their antitumor activities against A549 and NCIH23 lung cancer cells were validated. In order to obtain full profile of anticancer activity, cells viability (MTS) assays were combined with cell proliferation (BrdU) assays which measure actively dividing cells in treated sample. Experimental measurements showed good agreement between predicted and measured activities for majority of compounds. Also, anticancer activities of new pyrazole derivatives pointed to the chemical groups that can be useful in designing antitumor molecules. Substitution of hydrazine linker with rigid, 1,2,4-oxadiazole moiety resulted in compound 10, which has low (if any) cytotoxic activity and high potential cytostatic activity. Therefore, compound 10 presents a good starting point for design of new, more potent and safer anticancer therapeutics.

The synthesis, characterization and optical properties of novel, substituted, pyrazoly 1,3,4-oxadiazole derivatives

A series of novel substituted pyrazoly 1,3,4-oxadiazole derivatives were synthesized by the reaction of substituted pyrazole-5-carbohydrazide with substituted benzoic acid in the presence of phosphorus oxychloride. The compounds were characterised using I

Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells

A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives were synthesized, and the effects of all the compounds on A549 cell growth were investigated. The results showed that all the nine compounds had inhibitory effects on the growt