955094-26-5 Usage
Uses
Used in Bioconjugation:
α-Maleimidopropionyl-ω-succinimidyl-2(ethylene glycol) is used as a crosslinker for bioconjugation applications. It facilitates the covalent attachment of amine-containing molecules to thiol-containing molecules, forming stable linkages between them.
Used in Drug Delivery Systems:
In the pharmaceutical industry, α-Maleimidopropionyl-ω-succinimidyl-2(ethylene glycol) is used as a component in drug delivery systems. It helps in the development of targeted drug delivery systems by enabling the attachment of therapeutic agents to carrier molecules, such as nanoparticles or liposomes, through stable covalent bonds.
Used in Protein Engineering:
In the field of protein engineering, α-Maleimidopropionyl-ω-succinimidyl-2(ethylene glycol) is used as a tool for protein modification. It allows for the attachment of functional groups or other proteins to specific sites on a target protein, enabling the creation of chimeric proteins or the modification of protein function.
Used in Biosensor Development:
In the development of biosensors, α-Maleimidopropionyl-ω-succinimidyl-2(ethylene glycol) is used as a linker to immobilize biomolecules, such as enzymes or antibodies, onto sensor surfaces. This immobilization process enhances the stability and sensitivity of the biosensors, allowing for accurate detection and measurement of target analytes.
Check Digit Verification of cas no
The CAS Registry Mumber 955094-26-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,5,0,9 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 955094-26:
(8*9)+(7*5)+(6*5)+(5*0)+(4*9)+(3*4)+(2*2)+(1*6)=195
195 % 10 = 5
So 955094-26-5 is a valid CAS Registry Number.
955094-26-5Relevant articles and documents
Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
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, (2019/11/11)
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
Preparation method of protein cross-linking agent maleimide-dipolyethylene glycol-acrylic acid succinimide ester
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Paragraph 0041; 0043; 0044, (2019/04/26)
The invention relates to the technical field of organic chemical synthesis, and in particular relates to a preparation method of a protein cross-linking agent maleimide-dipolyethylene glycol-acrylic acid succinimide ester. The method comprises the following steps: step 1, synthesizing 3-maleimide propionyl chloride; step 2, synthesizing maleimide-dipolyethylene glycol-acrylic acid; step 3, synthesizing maleimide-dipolyethylene glycol-acryloyl chloride; and step 4, synthesizing the maleimide-dipolyethylene glycol-acrylic acid succinimide ester. An acyl chloride reagent adopted by the method foran esterification reaction is cheaper than a condensation reagent, the costs can be reduced, the purification is convenient, and removal of by-products of the condensation reagent is avoided; and themethod is suitable for industrialized production.
POLYMER LINKERS AND THEIR USES
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Paragraph 0291-0292, (2019/04/08)
Provided herein are poly-1-hydroxymethylethylene hydroxymethyl formal (PHF)-based drug delivery systems. Also disclosed are methods of making antibodydrug conjugates and methods of treatment using these conjugates.
