955328-25-3Relevant articles and documents
Superacidic Cyclization of Activated Anthranilonitriles into 2-Unsubstituted-4-aminoquinolines
Lavrard, Hubert,Larini, Paolo,Popowycz, Florence
, p. 4203 - 4206 (2017/08/23)
4-Aminoquinolines were prepared in a three-step synthesis starting from substituted anthranilonitriles. The condensation on 1,1,1-trichloro-4-ethoxybut-3-enone proceeded efficiently either neat or in refluxing EtOH. Cyclization in superacidic trifluoromethanesulfonic acid provided unstable intermediate, which upon treatment with NaOEt in ethanol, afforded the expected esters. Theoretical investigations pointed out a monoprotonated nitrilium as the reactive species during the cyclization process.
Synthesis of new quinoline fused heterocycles such as benzo[h]-1,6- naphthyridines and pyrazolo[4,3 c]quinolines
Ghotekar, Bhausaheb Kedarnath,Ghagare, Maruti G.,Toche, Raghunath B.,Jachak, Madhukar N.
experimental part, p. 169 - 175 (2010/08/05)
Synthesis of novel benzo[h]-1,6-naphthyridines was successfully achieved by cyclocondensation of ethyl 4-aminoquinoline-3-carboxylates with malononitrile. The pyrazolo[4,3-c]quinolines were synthesized by nucleophilic substitution and subsequent addition
