955413-26-0

Basic information

• Product Name: 6-trifluoroMethyl-8-quinolinaMine
• Synonyms: 6-trifluoroMethyl-8-quinolinaMine
• CAS NO: 955413-26-0
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.1711896
• EINECS: -0
• Product Categories: organic building block
• Mol File: 955413-26-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-trifluoroMethyl-8-quinolinaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-trifluoroMethyl-8-quinolinaMine(955413-26-0)
• EPA Substance Registry System: 6-trifluoroMethyl-8-quinolinaMine(955413-26-0)

Safety Data

• Hazardous Substances Data: 955413-26-0(Hazardous Substances Data)

Upstream product

• 955413-30-6 8-nitro-6-(trifluoromethyl) quinoline 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 

Relevant articles and documents

Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

Synthesis of fluorine-containing 1,10-phenanthrolines using mild versions of Skraup and Doebner-von Miller reactions

A versatile route for the synthesis of new 1,10-phenanthroline derivatives with fluorine-containing groups is described. Skraup reactions were performed with yields of 19 up to 48% and overall yields of 5 up to 13% based on different fluorinated anilines as starting materials. Ten formerly unknown derivatives were synthesized and characterized by NMR spectroscopy (1H,13C,19F), ESI mass spectrometry and elemental analysis.

Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents

In the search of novel chemotherapeutic agents for emerging drug resistant parasites, the hybridization approaches have successfully emerged as an efficient tool in malarial chemotherapy. Herein, a rational design and synthesis of novel 8-aminoquinoline and pyrazolopyrimidine hybrids and their antimalarial activity against wild type Plasmodium falciparum (Pf-NF54) and resistant strain (Pf-K1) is reported. The medicinal chemistry approach to expand the scope of this series resulted in an identification of potent compounds with nanomolar potency (best IC50 5-10 nM). Systematic structure activity relationship (SAR) studies revealed that pyrazolopyrimidine and 8-aminoquinoline ring are essential for achieving good P. falciparum potency. The docking study revealed that the compound 6 can retain some of the critical interactions within pfDHODH drug target.

Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation

Disclosed herein are angiogenesis inhibitors represented by formula (I) or formula (II): The variables for formulas (I) and (II) are defined herein.