95548-68-8Relevant academic research and scientific papers
Arylidenemalononitriles in Heterocyclic Syntheses: a Novel Synthesis of Pyridopyrimidines
Gogoi, Mukti,Bhuyan, Pulakjyoti,Sandhu, Jagir S.,Baruah, Jogendra N.
, p. 1549 - 1550 (1984)
Arylidenemalononitriles react with 6-amino and 6-hydroxyamino-1,3-dimethyl- and 3-methyl-pyrimidine-2,4(1H,3H)-dione to give pyridopyrimidines in good yields.
New strategy for the oxidation of Hantzsch 1,4-dihydropyridines and dihydropyrido[2,3-d]pyrimidines catalyzed by DMSO under aerobic conditions
Saini, Anil,Kumar, Sanjay,Sandhu, Jagir S.
, p. 2317 - 2324 (2008/02/09)
A novel metal-salt-oxidant-free, efficient, and economical method for the oxidation of Hantzsch 1,4-dihydropyridines that uses aerial oxygen and solvent-grade dimethylsulfoxide is described. Also, the synthesis of pyrido[2,3-d]pyrimidines is achieved from in situ oxidation of dihydropyrido[2,3-d]pyrimidines that arise from the reaction of 6-aminouracils and cyano olefins in dimethylsulfoxide. Copyright Taylor & Francis Group, LLC.
A novel three-component one-pot synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines using microwave heating in the solid state
Devi, Ipsita,Kumar,Bhuyan, Pulak J.
, p. 8307 - 8310 (2007/10/03)
Microwave-assisted three-component cyclocondensation of barbituric acids 1, benzaldehyde 2 and alkyl nitriles 3 proceeds in the absence or presence of triethylamine to afford pyrano[2,3-d]pyrimidines 4 and 6-aminouracils 5 or 6-hydroxyaminouracils 6 react with 2 and 3 under identical conditions to yield pyrido[2,3-d]pyrimidines 7, all in high yields.
Studies on Uracils. 10. A Facile One-Pot Synthesis of Pyrido- and Pyrazolopyrimidines
Bhuyan, Pulakjyoti,Boruah, Romesh Chandra,Sandhu, Jagir Singh
, p. 568 - 571 (2007/10/02)
The reaction of functionalised uracils bearing amino and hydroxyamino groups at C-6 position (4 and 5) with strongly electrophilic cyano olefins (1,2 and 3) gave rise to pyridopyrimidines 7-9 in excellent yields.Hydrazine-substituted uracil 6 gave access to an efficient one-step synthesis of pyrazolopyrimidines 10.The capture of an eliminated hydrogen molecule by cyano olefins in the case of their reaction with 4 and 6 was confirmed by the isolation of dihydrocyano olefins.This fact further supported the plausible mechanism for the formation of compounds 7-10 via dihydropyrido- and dihydropyrazolopyrimidine intermediates A and C.
