95568-74-4Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists
McCalmont, William F.,Heady, Tiffany N.,Patterson, Jaclyn R.,Lindenmuth, Michael A.,Haverstick, Doris M.,Gray, Lloyd S.,Macdonald, Timothy L.
, p. 3691 - 3695 (2007/10/03)
This paper describes the synthesis of several novel T-type calcium channel antagonists that inhibit calcium influx into the cell, which in turn regulates unknown aspects of the cell cycle pathway that are responsible for cellular proliferation. A library of compounds was synthesized anda brief structure activity relationship will be described. From these studies we have identified a compound (1) that displays anti-proliferative activity in the low micromolar range across a variety of cancer cell lines.
Asymmetric Synthesis Using Chirally Modified Borohydrides. Part 2. Enantioselective Reduction of Ketones with Polymeric (S)-Prolinol-Borane Reagent
Itsuno, Shinichi,Ito, Koichi,Hirao, Akira,Nakahama, Seiichi
, p. 2887 - 2893 (2007/10/02)
Chiral polymeric reagents have been prepared from polymeric (S)-prolinols and borane and used in the enantioselective reduction of a series of prochiral ketones under various conditions.Reductions with these polymeric reagents are shown to give alcohols of reasonably good optical purity (up to 80percent).The results are compared to those obtained with (S)-N-benzylprolinol-borane complex which is a soluble model reagent.
