95578-13-5

Basic information

• Product Name: 5H-1,4-Benzodiazepine, 2,3-diphenyl-
• CAS NO: 95578-13-5
• Molecular Formula: C21H16N2
• Molecular Weight: 296.371
• Mol File: 95578-13-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5H-1,4-Benzodiazepine, 2,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-1,4-Benzodiazepine, 2,3-diphenyl-(95578-13-5)
• EPA Substance Registry System: 5H-1,4-Benzodiazepine, 2,3-diphenyl-(95578-13-5)

Safety Data

• Hazardous Substances Data: 95578-13-5(Hazardous Substances Data)

Upstream product

• 134-81-6 benzil 
• 4403-69-4 2-amino-1-benzylamine 
• 72040-08-5 diphenylchloroazirine 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 501-65-5 diphenyl acetylene 

Downstream Products

• 948-65-2 2-phenyl-indole 

Relevant articles and documents

Efficient Construction of 5H-1,4-Benzodiazepine Derivatives by a Catalyst-Free Direct Aerobic Oxidative Annulation Strategy

A catalyst-free direct aerobic oxidative annulation reaction of 2-aminobenzylic amines and α-hydroxy ketones efficiently afforded versatile 5H-1,4-benzodiazepine derivatives by employing air as economic and green oxidant under mild conditions. Interestingly, solvent was found to be crucial to the reaction, so that by using acetic acid as the best solvent an efficient and practical method could be achieved, requiring no catalysts or additives at all. This method tolerates a wide range of 2-aminobenzylic amines and α-hydroxy ketones and could be scaled up to multigram synthesis and directly applied in one-step synthesis of the pharmaceutically active N-desmethylmedazepam derivatives, revealing the potential of this new method in the synthesis of 5H-1,4-benzodiazepine skeleton-based pharmaceuticals and chemicals.

Synthesis method of 5H-1,4-benzodiazepine compound

The invention discloses a synthetic method of a 5H-1,4-benzodiazepine compound. According to the synthetic method, under the action of acid, air is used as an oxidizing agent, and an o-aminobenzylamine compound and 2-hydroxy-2-phenylacetophenone are subjected to a cascade reaction to prepare the 5H-1,4-benzodiazepine heterocyclic compound in one step. According to the method, expensive transitionmetal catalysts and ligands do not need to be used, the solvent acid is used as an accelerant, and other metal catalysts and a large amount of oxidizing agents are not needed, so the produced compoundis free of transition metal residues and suitable for being used as a precursor for medicine preparation; and the method is simple in condition, easy to operate and low in equipment requirements, aircan be used as an economical, safe and environment-friendly oxidizing agent, the solvent acid is used as the accelerant, the unique byproduct is water, and atom economy is high.