95586-94-0

Upstream product

• 123836-64-6 <<(1α,3β,5Z,7E)-3-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-fluoro-9,10-secocholesta-5,7,10(19)-trien-25-yl>oxy>-trimethylsilane 
• 123836-59-9 <3R-(1E,3α,5α)>-<3-Hydroxy-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic Acid Ethyl Ester 
• 123836-51-1 <2S-(1E,2α,3α,5α)>-<3-(Acetyloxy)-2-hydroxy-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic Acid Ethyl Ester 
• 81506-17-4 <2S-(1E,2α,3β,5α)>-<2-(acetyloxy)-3-hydroxy-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester 
• 123836-58-8 <3R-(1E,3α,5α)>-<3-(Acetyloxy)-2-methylene-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>cyclohexylidene>acetic Acid Ethyl Ester 
• 123836-54-4 <2S-(1E,2α,3α,5α)>-<3,5-Bis(acetyloxy)-2-<<(2,2,2-trichloroethoxy)carbonyl>oxy>-2-methylcyclohexylidene>acetic Acid Ethyl Ester 
• 123836-56-6 <2S-(1E,2α,3α,5α)>-<3-(Acetyloxy)-2-<<(2,2,2-trichloroethoxy)carbonyl>oxy>-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylcyclohexylidene>acetic Acid Ethyl Ester 
• 95511-54-9 6β-acetoxy-1α-fluoro-2β,3β-isopropylidenedioxy-5α-cholan-24-al 
• 95511-53-8 6β,24-acetoxy-1α-fluoro-24-hydroxy-2β,3β-isopropylidenedioxy-5α-cholane 
• 95511-56-1 1α-fluoro-2β,25-dihydroxy-3β-(tert-butyldimethylsiloxy)cholest-5-ene 
• 95511-61-8 3β-acetoxy-1α-fluoro-25-hydroxycholesta-5,7-diene 
• 95511-58-3 (R)-6-[(1S,3R,8S,9S,10R,13R,14S,17R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-fluoro-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptan-2-ol 
• 95511-60-7 Acetic acid (1S,3R,8S,9S,10R,13R,14S,17R)-1-fluoro-17-((R)-5-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 95511-55-0 1α-fluoro-25-hydroxy-2β,3β-isopropylidenedioxycholest-5-ene 

Relevant academic research and scientific papers

Immunosuppressive agents

The invention relates to pharmaceutical compositions comprising at least one Vitamin D derivative and a method of using the pharmaceutical compositions in suppressing immune responses.

Synthesis and biological activity of 1α-fluoro-25-hydroxyvitamin D3

trans Diaxial opening with potassium hydrogen difluoride of the 1β,2β-epoxy-3β-ol derived from cholenic acid gave the 1α-fluoro-2β,3β-diol derivative. Construction of the 25-hydroxy cholesterol side chain and deoxygenation of the 2β-hydroxy group afforded