95586-94-0

Basic information

• Product Name: 1α-Fluoro-25-hydroxycholecalciferol
• Synonyms: 1α-Fluoro-25-hydroxycholecalciferol
• CAS NO: 95586-94-0
• Molecular Weight: 418.636
• Mol File: 95586-94-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1α-Fluoro-25-hydroxycholecalciferol(CAS DataBase Reference)
• NIST Chemistry Reference: 1α-Fluoro-25-hydroxycholecalciferol(95586-94-0)
• EPA Substance Registry System: 1α-Fluoro-25-hydroxycholecalciferol(95586-94-0)

Safety Data

• Hazardous Substances Data: 95586-94-0(Hazardous Substances Data)

Upstream product

• 95511-54-9 6β-acetoxy-1α-fluoro-2β,3β-isopropylidenedioxy-5α-cholan-24-al 
• 95511-53-8 6β,24-acetoxy-1α-fluoro-24-hydroxy-2β,3β-isopropylidenedioxy-5α-cholane 
• 95511-56-1 1α-fluoro-2β,25-dihydroxy-3β-(tert-butyldimethylsiloxy)cholest-5-ene 
• 95511-61-8 3β-acetoxy-1α-fluoro-25-hydroxycholesta-5,7-diene 
• 95511-58-3 (R)-6-[(1S,3R,8S,9S,10R,13R,14S,17R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-fluoro-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptan-2-ol 
• 95511-60-7 Acetic acid (1S,3R,8S,9S,10R,13R,14S,17R)-1-fluoro-17-((R)-5-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 95511-55-0 1α-fluoro-25-hydroxy-2β,3β-isopropylidenedioxycholest-5-ene 
• 95529-30-9 1α-fluoro-2β,3β-isopropylidenedioxycholesta-5,24-diene 
• 95529-29-6 1α-fluoro-6β-hydroxy-2β,3β-isopropylidenedioxy-5α-cholest-24-ene 
• 95511-59-4 1α-fluoro-3β,25-dihydroxycholest-5-ene 
• 95511-62-9 1α-fluoro-25-hydroxyvitamin D3 3-acetate 
• 123930-10-9 <3S-(1Z,3β,5α)>-<3-Fluoro-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic Acid Ethyl Ester 
• 123836-60-2 <3S-(1E,3β,5α)>-<3-Fluoro-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic Acid Ethyl Ester 
• 123836-56-6 <2S-(1E,2α,3α,5α)>-<3-(Acetyloxy)-2-<<(2,2,2-trichloroethoxy)carbonyl>oxy>-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylcyclohexylidene>acetic Acid Ethyl Ester 

Relevant articles and documents

Total synthesis of 1α-fluoro-25-hydroxycholecalciferol and -ergocalciferol

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Synthesis and biological activity of 1α-fluoro-25-hydroxyvitamin D3

trans Diaxial opening with potassium hydrogen difluoride of the 1β,2β-epoxy-3β-ol derived from cholenic acid gave the 1α-fluoro-2β,3β-diol derivative. Construction of the 25-hydroxy cholesterol side chain and deoxygenation of the 2β-hydroxy group afforded