95587-14-7

Basic information

• Product Name: (+)-(S)-trans-2-heptyl-5-butylpyrrolidine
• Synonyms: (+)-(S)-trans-2-heptyl-5-butylpyrrolidine
• CAS NO: 95587-14-7
• Molecular Weight: 225.418
• Mol File: 95587-14-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (+)-(S)-trans-2-heptyl-5-butylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(S)-trans-2-heptyl-5-butylpyrrolidine(95587-14-7)
• EPA Substance Registry System: (+)-(S)-trans-2-heptyl-5-butylpyrrolidine(95587-14-7)

Safety Data

• Hazardous Substances Data: 95587-14-7(Hazardous Substances Data)

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 629-04-9 1-Bromoheptane 
• 195299-15-1 2-cyano-5-oxazolopyrrolidine 
• 105147-73-7 1-[(2R,5R)-5-(2-Hydroxy-butyl)-pyrrolidin-2-yl]-heptan-2-ol 
• 109-72-8 n-butyllithium 
• 1179523-35-3 C₁₁H₂₁N 
• 131403-22-0 (2S,5R)-2-Butyl-5-formyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 4762-26-9 hexyltriphenylphosphonium bromide 
• 105147-71-5 1-((R)-1-Oxy-3,4-dihydro-2H-pyrrol-2-yl)-heptan-2-ol 
• 105147-72-6 1-((2S,3aR,6R)-2-Ethyl-hexahydro-pyrrolo[1,2-b]isoxazol-6-yl)-heptan-2-ol 
• 105147-70-4 (2R,3aR)-2-Pentyl-hexahydro-pyrrolo[1,2-b]isoxazole 
• 111964-17-1 (3R,7aS)-5-Heptyl-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile 
• 111964-18-2 (3R,5S,7aS)-5-Heptyl-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 95513-28-3 (2R)-trans-1-(phenylsulfonyl)-2-(1-<(phenylsulfonyl)oxy>butyl)-5-heptylpyrrolidine 

Downstream Products

• 105147-82-8 (2S,5R)-1-Benzyl-2-butyl-5-heptyl-pyrrolidine 
• 112020-14-1 (+)-(S)-trans-2-heptyl-5-butyl-1-benzyl pyrrolidine 
• 95587-13-6 (+)-(S)-trans-2-heptyl-5-butyl-1-phenyl sulfonyl pyrrolidine 
• 105147-76-0 ((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-phenyl-methanone 
• 111964-20-6 (S)-1-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propan-1-one 

Relevant articles and documents

Enantioselective syntheses of 2-substituted pyrrolidines from allylamines by domino hydroformylation-condensation: Short syntheses of (S)-nicotine and the alkaloid 225C

Short routes to chiral 2-substituted pyrrolidines based on rhodium-catalyzed hydroformylations of allylamines and their N-alkyl and N-acyl derivatives, which were prepared by asymmetric allylic substitutions, are described. The outcome of the hydroformyla

Organolanthanide-catalyzed hydroamination/cyclization. Efficient allene- based transformations for the syntheses of naturally occurring alkaloids

The total syntheses of the pyrrolidine alkaloid (+)-197B (1) and pyrrolizidine alkaloid (+)-xenovenine (2) are described. The strategy involves enantioselective syntheses of the aminoallene, (5S,8S)-5-amino- trideca-8,9-diene (3), and the aminoallene-alkene, (5S)-5-amino-pentadeca- 1,8,9-triene (4), which then undergo regio- and stereoselective cyclohydroamination catalyzed by the organolanthanide precatalysts Cp'2LnCH(TMS)2 and Me2SiCp''((t)BuN)LnN(TMS)2 (Cp' = η5-Me5C5; Cp'' = η5-Me4C5; Ln = lanthanide; TMS = Me3Si). These reactive organolanthanide complexes efficiently mediate highly diastereoselective intramolecular hydroamination/cyclization (IHC) reactions under mild conditions. The turnover-limiting step in these catalytic cycles is proposed to be intramolecular insertion into the Ln-N bond of the proximal allenic C=C linkage, followed by rapid protonolytic cleavage of the resulting Ln-C bond. The rate and selectivity of the insertion process is highly sensitive to the steric demands of the substrate.

ASYMMETRIC SYNTHESIS XII: STEREOCONTROLLED ELECTROPHILIC-NUCLEOPHILIC α,α'-SUBSTITUTION OF THE PYRROLIDINE RING.

The synthesis of 2-cyano-5-oxazolopyrrolidine 3, a chiral pyrrolidine synthon, is described.Conditions were established that permitted sequential chemoselective reactions at the C-2 aminonitrile (electrophilic substitution) and at the C-5 aminoether (nucl