955938-07-5Relevant academic research and scientific papers
LANTHANIDE (III) ION COMPLEXING COMPOUNDS, LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS
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Page/Page column 23; 32, (2009/03/07)
Lanthanide (III) ion complexing compound comprising: (1) a sensitizer moiety of formula (I) in which: a is an integer from 1 to 4; b is an integer equal 1 or 2; c is an integer equal to 1 or 2; (R1)a, (R2)b, (R3)C are the
Emissive and cell-permeable 3-pyridyl- and 3-pyrazolyl-4-azaxanthone lanthanide complexes and their behaviour in cellulo
Montgomery, Craig P.,New, Elizabeth J.,Palsson, Lars O.,Parker, David,Batsanov, Andrei S.,Lamarque, Laurent
experimental part, p. 2186 - 2213 (2010/03/30)
A series of seven emissive europium(III) and terbium(III) complexes was prepared, incorporating a 3-pyridyl-4-azaxanthone or 3-pyrazolyl-4-azaxanthone sensitising moiety within a polydentate macrocyclic ligand. High overall emission quantum yields in aqueous media are attenuated in the presence of protein or certain oxy anions due to displacement of the N,N′-chelated sensitiser. Nevertheless, these complexes are taken into cells and tend to localise over the first few hours in mitochondria before being trafficked to endosomal compartments. Cell uptake studies, in the presence of competitive inhibitors or promoters of well-defined uptake pathways, reveal a common uptake mechanism involving macropinocytosis.
Effective and efficient sensitisation of terbium luminescence at 355 nm with cell permeable pyrazoyl-1-azaxanthone macrocyclic complexes
Montgomery, Craig P.,Parker, David,Lamarque, Laurent
, p. 3841 - 3843 (2008/03/13)
Emissive terbium complexes, suitable for protein conjugation, incorporating a pyrazoyl-1-aza-xanthone chromophore have been prepared; they exhibit cellular uptake and possess a much lower sensitivity to excited state quenching. The Royal Society of Chemis
