955938-70-2Relevant academic research and scientific papers
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity
Feng, Zixia,Mohapatra, Suchismita,Klimko, Peter G.,Hellberg, Mark R.,May, Jesse A.,Kelly, Curtis,Williams, Gary,McLaughlin, Marsha A.,Sharif, Najam A.
, p. 2998 - 3002 (2008/02/05)
A series of 8-substituted benzodifuran analogs was prepared and evaluated for 5-HT2A receptor binding and activation. Several compounds containing ether and ester functionality were found to be potent agonists. Topical ocular administration of 5, 18, and 25 effectively reduced intra-ocular pressure in the hypertensive cynomolgus monkey eye in the range of 25-37%.
