955954-05-9Relevant articles and documents
Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin
Peri?, Mihaela,Fajdeti?, Andrea,Rup?i?, Renata,Alihod?i?, Sulejman,?iher, Dinko,Bukvi? Kraja?i?, Mirjana,Smith, Kirsten S.,Ivezi?-Sch?nfeld, Zrinka,Padovan, Jasna,Landek, Goran,Jeli?, Dubravko,Hutinec, Antun,Mesi?, Milan,Ager, Arba,Ellis, William Y.,Milhous, Wilbur K.,Ohrt, Colin,Spaventi, Radan
, p. 1389 - 1401 (2012)
Novel classes of antimalarial drugs are needed due to emerging drug resistance. Azithromycin, the first macrolide investigated for malaria treatment and prophylaxis, failed as a single agent and thus novel analogues were envisaged as the next generation w
Microwave-assisted polymer-supported acylation of 15-membered azalides - A rapid and efficient procedure
Hutinec, Antun,Rup?i?, Renata,?aleta, Irena,Or?uli?, Mislav
experimental part, p. 1745 - 1748 (2011/05/05)
The application of microwave heating to a polymer-assisted solution phase synthesis technique has been used to develop a rapid and efficient protocol for the solution phase synthesis of amides from unprotected polyfunctional 15-membered azalides.
9A-SUBSTITUTED AZALIDES
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, (2008/06/13)
The present invention relates to novel 9a-substituted azalides having antimalarial activity. More particularly, the invention relates to 9a-substituted 9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A, 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythr