956-62-7Relevant academic research and scientific papers
COMPOUNDS USEFUL IN HIV THERAPY
-
Page/Page column 146, (2020/06/19)
The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.
Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates
Mampuys, Pieter,Zhu, Yanping,Sergeyev, Sergey,Ruijter, Eelco,Orru, Romano V. A.,Van Doorslaer, Sabine,Maes, Bert U. W.
supporting information, p. 2808 - 2811 (2016/07/06)
A new method for the synthesis of secondary thiocarbamates from readily available isocyanides and thiosulfonates with broad functional group tolerance is reported. The reaction proceeds under mild reaction conditions in isopropanol and is catalyzed by inexpensive sodium iodide.
Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids
Goldeman, Waldemar,Nasulewicz-Goldeman, Anna
supporting information, p. 3475 - 3479 (2014/07/22)
A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, 5f and 5j) showed a similar or higher anti-proliferative activity than zoledronic acid.
Synthesis, characterization and mechanochromic behavior of binuclear gold (I) complexes with various diisocyano bridges
Liang, Jinhua,Hu, Fang,Lv, Xiaoyi,Chen, Zhao,Chen, Zhiming,Yin, Jun,Yu, Guang-Ao,Liu, Sheng Hua
, p. 485 - 490 (2012/10/30)
A series of binuclear gold (I) complexes were synthesized. Their structures were characterized by elemental analyses, IR spectrometry, UV-Vis spectroscopy and single crystal X-ray diffraction. Their fluorescent mechanochromic (tribochromic) properties were investigated. The results of the mechanochromic studies suggested that the gold complexes with methylsubstituted phenyl bridges exhibited mechanochromism and a 100 nm red-shift of fluorescent spectrum could be observed after grinding. The complex with a diphenylmethane bridge exhibited mechanochromism with a change in fluorescence from green to blue (25 nm red-shift after grinding). The ground complexes reverted to their original states by treatment with CH2Cl2. No mechanochromism was observed for either the biphenyl or diphenylethane containing complexes.
α-Thioxothioamides: A formal [4+1] cycloaddition reaction with isocyanides and diisocyanides and its application to a new straightforward formation of extended tetrathiafulvalenes
Morel, Georges,Marchand, Evelyne,Sinbandhit, Sourisak,Carlier, Roger
, p. 655 - 662 (2007/10/03)
A number of 2-(alkylimino) and 2-(arylimino)-l,3-dithioles (aza DTFs) bearing push-pull substituents have been prepared under mild conditions according to the title procedure. This novel strategy relies upon the fact that the use of conjugated diisocyanides allows an effective synthesis of new extended tetrathiafulvalenes (TTFs). The two dithiole moieties are linked by a conjugated framework that incorporates a phenyl, biphenyl or azobiphenyl group. High and low temperature measurements are required in order to understand the complex 1H and 13C NMR spectra of the prepared mono-bis- and tris-(1,3-dithiole) derivatives. Their electrochemical oxidations are also described.
