956-90-1

Basic information

• Product Name: PHENCYCLIDINE HYDROCHLORIDE
• Synonyms: 1-(1-phenylcyclohexyl)-piperidinhydrochloride;cn-25,253-2;elysion;gp-121;mcv4158;nih9580;nsc-40902;pcphydrochloride
• CAS NO: 956-90-1
• Molecular Formula: C₁₇H₂₅N*ClH
• Molecular Weight: 279.85
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 956-90-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 233-235°C
• Boiling Point: 340°C at 760 mmHg
• Flash Point: 144.5°C
• Appearance: /
• Vapor Pressure: 8.86E-05mmHg at 25°C
• Storage Temp.: Store at RT
• Solubility: H2O: 11.2 mg/mL
• CAS DataBase Reference: PHENCYCLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENCYCLIDINE HYDROCHLORIDE(956-90-1)
• EPA Substance Registry System: PHENCYCLIDINE HYDROCHLORIDE(956-90-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 36/37-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: TN2272600
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 956-90-1(Hazardous Substances Data)

Usage

Description

Phencyclidine hydrochloride (PCP) is a psychoactive drug that has inhibitory, excitatory, analgesic and hallucinogenic effects on the central nervous system. Its chemical name is 1-(1-phenylcyclohexane)piperidine. It is a dissociative drug once used by anesthesiologists as an anesthetic with hallucinogenic and neurotoxic effects.

Chemical Properties

Crystalline Solid

Uses

Controlled substance (depressant). Anesthetic (intravenous).

Biological Activity

Non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.

Biochem/physiol Actions

σ opioid receptor agonist and psychostimulant; inhibits NMDA glutamate receptor activation by binding to an allosteric site within the ion channel.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Human systemic effects by ingestion and intravenousroutes: distorted perceptions, euphoria, excitement,hallucinations, and paresthesia. An experimental teratogen.Other experime

InChI:InChI=1/C17H25N.ClH/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18;/h1,4-5,10-11H,2-3,6-9,12-15H2;1H

Upstream product

• 108-86-1 bromobenzene 
• 3867-15-0 1-piperidinocyclohexylcarbonitrile 
• 110-89-4 piperidine 
• 108-94-1 cyclohexanone 

Downstream Products

• 60232-85-1 1-(1-phenylcyclohexyl)-4-hydroxypiperidine 
• 78165-06-7 r-4-phenyl-4-(1-piperidinyl)-t-cyclohexanol 
• 78165-07-8 r-4-phenyl-4-(1-piperidinyl)-c-cyclohexanol 

Relevant articles and documents

New morpholine analogues of phencyclidine: Chemical synthesis and pain perception in rats

Phencyclidine (PCP, I) and most its derivatives have demonstrated some pharmacological effects. Accordingly, in this study, the new methoxy (III) and hydroxy-methyl (IV) morpholine PCP derivatives were synthesized. The acute and chronic pain activities of these drugs (III, IV) were investigated by tail immersion and formalin tests on rats and the results were compared with those in PCP, PCM (PCP-morpholine, II), and methyl-PCM (V). Findings indicated that III (6 mg/kg, i.p.) generates more analgesic effects in tail immersion test in comparison with I and II in 20, 40, 45 and 55 min post-injection. These effects were observed in 10, 20, 40, 45 and 50 min after the application of IV (at the same dosage). This analgesic effect was markedly seen in 20, 40, 45 and 50 min after compound IVs application in comparison with the drugs (I-V). In formalin test analysis, the acute chemical pain (Phase I) could not be affected by any drugs (I-V) while chronic formalin pain would be diminished by these new synthesized drugs (III and IV), especially in late Phase II, compared to I and II at the dosage of 6 mg/kg. It is, therefore, concluded that these new synthesized PCP derivates including methoxy-PCM (III) and hydroxy-methyl-PCM (IV) could substantially and respectively diminish acute thermal and chronic chemical pains.