956019-14-0Relevant academic research and scientific papers
Imidazolopiperazines: Hit to lead optimization of new antimalarial agents
Wu, Tao,Nagle, Advait,Kuhen, Kelli,Gagaring, Kerstin,Borboa, Rachel,Francek, Caroline,Chen, Zhong,Plouffe, David,Goh, Anne,Lakshminarayana, Suresh B.,Wu, Jeanette,Ang, Hui Qing,Zeng, Peiting,Kang, Min Low,Tan, William,Tan, Maria,Ye, Nicole,Lin, Xuena,Caldwell, Christopher,Ek, Jared,Skolnik, Suzanne,Liu, Fenghua,Wang, Jianling,Chang, Jonathan,Li, Chun,Hollenbeck, Thomas,Tuntland, Tove,Isbell, John,Fischli, Christoph,Brun, Reto,Rottmann, Matthias,Dartois, Veronique,Keller, Thomas,Diagana, Thierry,Winzeler, Elizabeth,Glynne, Richard,Tully, David C.,Chatterjee, Arnab K.
, p. 5116 - 5130 (2011/09/16)
Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for this series of compounds is discussed, focusing on optimi
