956035-71-5Relevant academic research and scientific papers
Discovery of 1-{2-[(1S)-(3-dimethylamino-propionyl)amino-2-methylpropyl]-4- methyl-phenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia
Chen, Chen,Jiang, Wanlong,Tucci, Fabio,Tran, Joe A.,Fleck, Beth A.,Hoare, Sam R.,Joppa, Margaret,Markison, Stacy,Wen, Jenny,Sai, Yang,Johns, Michael,Madan, Ajay,Chen, Takung,Chen, Caroline W.,Marinkovic, Dragan,Arellano, Melissa,Saunders, John,Foster, Alan C.
, p. 5249 - 5252 (2007)
A potent and selective antagonist of the melanocortin-4 receptor, 1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-6-methylphenyl} -4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine (10d), was identified from a series piperazinebenzylamine a
