956092-99-2Relevant academic research and scientific papers
Transition-metal-free and chemoselective NaOtBu-O 2-mediated oxidative cleavage reactions of vic-1,2-diols to carboxylic acids and mechanistic insight into the reaction pathways
Kim, Sun Min,Kim, Dong Wan,Yang, Jung Woon
, p. 2876 - 2879 (2014)
A method for efficient oxidative cleavage of vic-1,2-diols using a NaO tBu-O2 system resulted in the formation of carboxylic acids in high yields. The present protocol is an eco-friendly alternative to a conventional transition-metal-based method. This new strategy allows large-scale production with nonchromatographic purification while also suppressing competitive reaction pathway such as benzilic acid rearrangement.
