956102-17-3Relevant academic research and scientific papers
The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor
Bailey, James M.,Scott, Jackie S.,Basilla, Jonathan B.,Bolton, Victoria J.,Boyfield, Izzy,Evans, David G.,Fleury, Etienne,Heightman, Tom D.,Jarvie, Emma M.,Lawless, Kirk,Matthews, Kim L.,McKay, Fiona,Mok, Hindy,Muir, Alison,Orlek, Barry S.,Sanger, Gareth J.,Stemp, Geoffrey,Stevens, Alexander J.,Thompson, Mervyn,Ward, John,Vaidya, Kalindi,Westaway, Susan M.
scheme or table, p. 6452 - 6458 (2010/05/02)
Optimisation of a series of benzazepine sulfonamide hit compounds identified from high throughput screening led to the discovery of a new series of tractable, potent motilin receptor agonists.
Studies towards the identification of a new generation of atypical antipsychotic agents
Garzya, Vincenzo,Forbes, Ian T.,Gribble, Andrew D.,Hadley, Mike S.,Lightfoot, Andrew P.,Payne, Andrew H.,Smith, Alexander B.,Douglas, Sara E.,Cooper, David G.,Stansfield, Ian G.,Meeson, Malcom,Dodds, Emma E.,Jones, Declan N.C.,Wood, Martyn,Reavill, Charlie,Scorer, Carol A.,Worby, Angela,Riley, Graham,Eddershaw, Peter,Ioannou, Chris,Donati, Daniele,Hagan, Jim J.,Ratti, Emiliangelo A.
, p. 400 - 405 (2007/10/03)
A rational structure-activity relationship study around compound (1) is reported. The lead optimisation programme led to the identification of sulfonamide (25), a molecule combining dopamine D2/D3 receptor antagonism with serotonin 5
