956111-34-5

Upstream product

• 36309-42-9 4-(trimethylsilyloxy)aniline 
• 57154-80-0 1,10-phenanthroline-2-carboxylic acid chloride 

Downstream Products

• 956111-36-7 1,10-phenanthroline-2-carboxamide-phenyl-4-ethoxypiperidine 
• 956111-26-5 1,10-phenanthroline-2-carboxamide-phenyl-4-ethoxypiperidine palladium(II) chloride 
• 956111-27-6 1,10-phenanthroline-2-carboxamide-phenyl-4-ethoxypiperidine platinum(II) chloride 
• 960071-60-7 C₁₂H₇N₂CONC₆H₄OHPtCl 

Relevant academic research and scientific papers

Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex

Two new mono-substituted phenanthroline ligands and their platinum(ii) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase. The Royal Society of

TELOMERASE INHIBITORS

The present invention relates to metal complexes of formulae (I), (IIa) or (IIb) which interaction with quadruplex DNA and act as inhibitors of telomerase activity, the synthesis of these complexes and their use in the treatment of cancer.